TY - JOUR
T1 - Anthropometric measures, body mass index, and pancreatic cancer
T2 - A pooled analysis from the pancreatic cancer cohort consortium (PanScan)
AU - Arslan, Alan A.
AU - Helzlsouer, Kathy J.
AU - Kooperberg, Charles
AU - Shu, Xiao Ou
AU - Steplowski, Emily
AU - Bueno-De-Mesquita, H. Bas
AU - Fuchs, Charles S.
AU - Gross, Myron D.
AU - Jacobs, Eric J.
AU - LaCroix, Andrea Z.
AU - Petersen, Gloria M.
AU - Stolzenberg-Solomon, Rachael Z.
AU - Zheng, Wei
AU - Albanes, Demetrius
AU - Amundadottir, Laufey
AU - Bamlet, William R.
AU - Barricarte, Aurelio
AU - Bingham, Sheila A.
AU - Boeing, Heiner
AU - Boutron-Ruault, Marie Christine
AU - Buring, Julie E.
AU - Chanock, Stephen J.
AU - Clipp, Sandra
AU - Gaziano, J. Michael
AU - Giovannucci, Edward L.
AU - Hankinson, Susan E.
AU - Hartge, Patricia
AU - Hoover, Robert N.
AU - Hunter, David J.
AU - Hutchinson, Amy
AU - Jacobs, Kevin B.
AU - Kraft, Peter
AU - Lynch, Shannon M.
AU - Manjer, Jonas
AU - Manson, Jo Ann E.
AU - McTiernan, Anne
AU - McWilliams, Robert R.
AU - Mendelsohn, Julie B.
AU - Michaud, Dominique S.
AU - Palli, Domenico
AU - Rohan, Thomas E.
AU - Slimani, Nadia
AU - Thomas, Gilles
AU - Tjønneland, Anne
AU - Tobias, Geoffrey S.
AU - Trichopoulos, Dimitrios
AU - Virtamo, Jarmo
AU - Wolpin, Brian M.
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne
AU - Patel, Alpa V.
PY - 2010/5/10
Y1 - 2010/5/10
N2 - Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95% CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.
AB - Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95% CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.
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U2 - 10.1001/archinternmed.2010.63
DO - 10.1001/archinternmed.2010.63
M3 - Article
C2 - 20458087
AN - SCOPUS:77952177097
SN - 0003-9926
VL - 170
SP - 791
EP - 802
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 9
ER -