TY - JOUR
T1 - Anthropometric indices and selenium status in British adults
T2 - The U.K. National Diet and Nutrition Survey
AU - Spina, Alexander
AU - Guallar, Eliseo
AU - Rayman, Margaret P.
AU - Tigbe, William
AU - Kandala, Ngianga Bakwin
AU - Stranges, Saverio
PY - 2013
Y1 - 2013
N2 - Recent studies have raised concern over possible associations between high selenium (Se) status and excess adiposity, known to be linked to adverse cardiometabolic outcomes. Studies of Se status in relation to adiposity are scarce in the United Kingdom. This study examined cross-sectional associations of anthropometric indices with Se-status biomarkers in a nationally representative sample of 1045 (577 female, 468 male) British Caucasian adults ages 19-64 who participated in the 2000-2001 National Diet and Nutrition Survey. Median (first, third quartile) values for whole-blood glutathione peroxidase (GPx) activity and plasma and erythrocyte Se concentrations were 120.0 (103.0, 142.4) nmol mg Hb-1 min-1, 1.08 (0.98, 1.20) μmol/L, and 1.62 (1.38, 1.91) μmol/L, respectively. For males, values were 119.0 (100.0, 141.0) nmol mg Hb-1 min-1, 1.09 (0.99, 1.22) μmol/L, and 1.54 (1.34, 1.79) μmol/L, respectively; for females 121.0 (105.0, 145.0) nmol mg Hb-1 min-1, 1.07 (0.97, 1.18) μmol/L, and 1.71 (1.43, 1.99) μmol/L, respectively. Multivariate adjusted mean differences (95% CI) in whole-blood GPx between the highest (>30 kg/m2) and the lowest (<25 kg/m2) categories of body mass index and the highest (96.5-139.2 cm) and the lowest (52.2-78.1 cm) quartiles of waist circumference (WC) were -7.9 (-13.2, -2.7) and -9.7 (-16.2, -3.2) nmol mg Hb-1 min-1, respectively. Difference (95% CI) in plasma Se between the third (87.5-96.4 cm) and the lowest quartiles of WC was -0.04 (-0.08, -0.03) μmol/L. Difference (95% CI) in red blood cell (RBC) Se between the highest (0.91-1.11) and the lowest (0.53-0.76) quartiles of waist-to-hip ratio (WHR) was 0.10 (0.00, 0.20) μmol/L. Similar results were observed in gender and menopausal-status subgroup analyses. The inverse association between plasma Se and WC and the positive association between RBC Se and WHR will need confirmation. The findings suggest associations between low whole-blood GPx activity and higher measures of general and central adiposity. Further experimental and randomized studies are needed to deduce the mechanisms and infer causality.
AB - Recent studies have raised concern over possible associations between high selenium (Se) status and excess adiposity, known to be linked to adverse cardiometabolic outcomes. Studies of Se status in relation to adiposity are scarce in the United Kingdom. This study examined cross-sectional associations of anthropometric indices with Se-status biomarkers in a nationally representative sample of 1045 (577 female, 468 male) British Caucasian adults ages 19-64 who participated in the 2000-2001 National Diet and Nutrition Survey. Median (first, third quartile) values for whole-blood glutathione peroxidase (GPx) activity and plasma and erythrocyte Se concentrations were 120.0 (103.0, 142.4) nmol mg Hb-1 min-1, 1.08 (0.98, 1.20) μmol/L, and 1.62 (1.38, 1.91) μmol/L, respectively. For males, values were 119.0 (100.0, 141.0) nmol mg Hb-1 min-1, 1.09 (0.99, 1.22) μmol/L, and 1.54 (1.34, 1.79) μmol/L, respectively; for females 121.0 (105.0, 145.0) nmol mg Hb-1 min-1, 1.07 (0.97, 1.18) μmol/L, and 1.71 (1.43, 1.99) μmol/L, respectively. Multivariate adjusted mean differences (95% CI) in whole-blood GPx between the highest (>30 kg/m2) and the lowest (<25 kg/m2) categories of body mass index and the highest (96.5-139.2 cm) and the lowest (52.2-78.1 cm) quartiles of waist circumference (WC) were -7.9 (-13.2, -2.7) and -9.7 (-16.2, -3.2) nmol mg Hb-1 min-1, respectively. Difference (95% CI) in plasma Se between the third (87.5-96.4 cm) and the lowest quartiles of WC was -0.04 (-0.08, -0.03) μmol/L. Difference (95% CI) in red blood cell (RBC) Se between the highest (0.91-1.11) and the lowest (0.53-0.76) quartiles of waist-to-hip ratio (WHR) was 0.10 (0.00, 0.20) μmol/L. Similar results were observed in gender and menopausal-status subgroup analyses. The inverse association between plasma Se and WC and the positive association between RBC Se and WHR will need confirmation. The findings suggest associations between low whole-blood GPx activity and higher measures of general and central adiposity. Further experimental and randomized studies are needed to deduce the mechanisms and infer causality.
KW - Adiposity
KW - Body mass index
KW - Erythrocyte selenium
KW - Free radicals
KW - Glutathione peroxidase
KW - Oxidative stress
KW - Plasma selenium
KW - Selenium
KW - Waist circumference
KW - Waist-to-hip ratio
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UR - http://www.scopus.com/inward/citedby.url?scp=84886156178&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2013.09.025
DO - 10.1016/j.freeradbiomed.2013.09.025
M3 - Article
C2 - 24095852
AN - SCOPUS:84886156178
SN - 0891-5849
VL - 65
SP - 1315
EP - 1321
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -