Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders

Monte S. Buchsbaum, Lynn E. Delisi, Henry H. Holcomb, John Cappelletti, Anna Catherine King, Jeannette Johnson, Erin Hazlett, Susan Dowling Zimmerman, Robert M. Post, John Morihisa, William Carpenter, Robert Cohen, David Pickar, Daniel Weinberger, Richard Margolin, Robert M. Kessler

Research output: Contribution to journalArticle

Abstract

Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron emission tomography in 16 patients with schizophrenia and 11 patients with affective disorder. Patients received no medication a minimum of 14 days and an average of 39.8 days. The subjects were administered the deoxyglucose 18F just before receiving a 34-minute 1/s series of unpleasant electrical stimuli to the right forearm while resting with eyes closed in a darkened, acoustically attenuated psychophysiologic testing chamber. Following monitored stimulation in the controlled environment, subjects were scanned and images converted to values of glucose use in micromoles per 100 g per minute according to Sokoloff's model. Data were analyzed with a four-way analysis of variance (ANOVA) with independent groups (normals, schizophrenics, and affectives) and repeated measures for slice level (supraventricular, midventricular, and infraventricular), hemisphere (right, left), and anteroposterior position (four sectors). Both normal subjects and patients showed a significant anteroposterior gradient in glucose use with highest values in the frontmost sector. Patients both with schizophrenia and with affective illness showed less of an anteroposterior gradient especially at superior levels, which was statistically confirmed by ANOVA. Absolute glucose levels in patients, which were actually higher in posterior regions rather than lower in frontal regions, were the largest contributors to the effect. Neither group differences in whole brain glucose use nor left-right asymmetries reached statistical significance. These results are consistent with our earlier reports of a relative hypofrontal function in schizophrenia compared with controls. This report extends this finding to affective illness, sharing a lack of diagnostic specificity with many biologic measures.

Original languageEnglish (US)
Pages (from-to)1159-1166
Number of pages8
JournalArchives of General Psychiatry
Volume41
Issue number12
DOIs
StatePublished - 1984
Externally publishedYes

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Mood Disorders
Schizophrenia
Glucose
Deoxyglucose
Analysis of Variance
Controlled Environment
Fluorine
Forearm
Positron-Emission Tomography
Affective
Brain

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Buchsbaum, M. S., Delisi, L. E., Holcomb, H. H., Cappelletti, J., King, A. C., Johnson, J., ... Kessler, R. M. (1984). Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders. Archives of General Psychiatry, 41(12), 1159-1166. https://doi.org/10.1001/archpsyc.1984.01790230045007

Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders. / Buchsbaum, Monte S.; Delisi, Lynn E.; Holcomb, Henry H.; Cappelletti, John; King, Anna Catherine; Johnson, Jeannette; Hazlett, Erin; Dowling Zimmerman, Susan; Post, Robert M.; Morihisa, John; Carpenter, William; Cohen, Robert; Pickar, David; Weinberger, Daniel; Margolin, Richard; Kessler, Robert M.

In: Archives of General Psychiatry, Vol. 41, No. 12, 1984, p. 1159-1166.

Research output: Contribution to journalArticle

Buchsbaum, MS, Delisi, LE, Holcomb, HH, Cappelletti, J, King, AC, Johnson, J, Hazlett, E, Dowling Zimmerman, S, Post, RM, Morihisa, J, Carpenter, W, Cohen, R, Pickar, D, Weinberger, D, Margolin, R & Kessler, RM 1984, 'Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders', Archives of General Psychiatry, vol. 41, no. 12, pp. 1159-1166. https://doi.org/10.1001/archpsyc.1984.01790230045007
Buchsbaum, Monte S. ; Delisi, Lynn E. ; Holcomb, Henry H. ; Cappelletti, John ; King, Anna Catherine ; Johnson, Jeannette ; Hazlett, Erin ; Dowling Zimmerman, Susan ; Post, Robert M. ; Morihisa, John ; Carpenter, William ; Cohen, Robert ; Pickar, David ; Weinberger, Daniel ; Margolin, Richard ; Kessler, Robert M. / Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders. In: Archives of General Psychiatry. 1984 ; Vol. 41, No. 12. pp. 1159-1166.
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