Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures

Marek A. Mirski, Ann C. McKeon, J. A. Ferrendelli

Research output: Contribution to journalArticlepeer-review

Abstract

Injection of γ-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injection into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalBrain research
Volume397
Issue number2
DOIs
StatePublished - Nov 12 1986
Externally publishedYes

Keywords

  • Anterior thalamus
  • Generalized seizure
  • Maximal electroshock
  • Pentylenetetrazol
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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