Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures

Marek A. Mirski; Ann C. McKeon; J. A. Ferrendelli

doi:10.1016/0006-8993(86)90642-6

Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures

Marek A. Mirski, Ann C. McKeon, J. A. Ferrendelli

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Injection of γ-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injection into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.

Original language	English (US)
Pages (from-to)	377-380
Number of pages	4
Journal	Brain research
Volume	397
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90642-6
State	Published - Nov 12 1986
Externally published	Yes

Keywords

Anterior thalamus
Generalized seizure
Maximal electroshock
Pentylenetetrazol
Substantia nigra

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)90642-6

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title = "Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures",

abstract = "Injection of γ-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injection into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.",

keywords = "Anterior thalamus, Generalized seizure, Maximal electroshock, Pentylenetetrazol, Substantia nigra",

author = "Mirski, {Marek A.} and McKeon, {Ann C.} and Ferrendelli, {J. A.}",

note = "Funding Information: Supported, in part, by NIH Grants NS 14834 and GM 07200, and by the Seay Neuropharmacology Research Fellowship.",

year = "1986",

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doi = "10.1016/0006-8993(86)90642-6",

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T1 - Anterior thalamus and substantia nigra

T2 - two distinct structures mediating experimental generalized seizures

AU - Mirski, Marek A.

AU - McKeon, Ann C.

AU - Ferrendelli, J. A.

N1 - Funding Information: Supported, in part, by NIH Grants NS 14834 and GM 07200, and by the Seay Neuropharmacology Research Fellowship.

PY - 1986/11/12

Y1 - 1986/11/12

N2 - Injection of γ-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injection into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.

AB - Injection of γ-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injection into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.

KW - Anterior thalamus

KW - Generalized seizure

KW - Maximal electroshock

KW - Pentylenetetrazol

KW - Substantia nigra

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EP - 380

JO - Brain research

JF - Brain research

IS - 2

ER -

Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures

Abstract

Keywords

ASJC Scopus subject areas

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