Anterior Segment Imaging in Ocular Surface Squamous Neoplasia

Sally Ong, Gargi K. Vora, Preeya K. Gupta

Research output: Contribution to journalReview article

Abstract

Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM) shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT) demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings. Although there are limitations to each of these imaging modalities, they can be useful adjunctive tools in the diagnosis of OSSN and could greatly assist the clinician in the management of OSSN patients. Nevertheless, anterior segment imaging has not replaced histopathology's role as the gold standard in confirming diagnosis.

Original languageEnglish (US)
Article number5435092
JournalJournal of Ophthalmology
Volume2016
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Neoplasms
Epithelium
Acoustic Microscopy
Optical Coherence Tomography
Confocal Microscopy
Neoplasm Metastasis
Intravital Microscopy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Anterior Segment Imaging in Ocular Surface Squamous Neoplasia. / Ong, Sally; Vora, Gargi K.; Gupta, Preeya K.

In: Journal of Ophthalmology, Vol. 2016, 5435092, 01.01.2016.

Research output: Contribution to journalReview article

Ong, Sally ; Vora, Gargi K. ; Gupta, Preeya K. / Anterior Segment Imaging in Ocular Surface Squamous Neoplasia. In: Journal of Ophthalmology. 2016 ; Vol. 2016.
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