Anterior insula lesions and alexithymia reduce the endorsements of everyday altruistic attitudes

Aileen Chau, Wanting Zhong, Barry Gordon, Frank Krueger, Jordan Grafman

Research output: Contribution to journalArticle

Abstract

Neuroimaging studies have reported a large network of brain regions involved in altruism. However, these studies are unable to determine if these regions are necessary for altruistic attitudes. Here, we examined the brain-basis of everyday altruistic attitudes ([Self-Report Altruism Scale]; e.g., helping a stranger with car troubles) and potential factors (i.e., alexithymia [Toronto Alexithymia Scale] such as empathic concern [Interpersonal Reactivity Index]) that may moderate this relationship. We carried out whole-brain voxel-based lesion-symptom mapping and region of interest analyses to study a large sample of patients (n = 130) with penetrating traumatic brain injuries. Our results showed that the effect of anterior insula (AI) lesions was moderated by alexithymia, but not empathic concern. The presence of AI lesions, as well as increased alexithymia, were associated with fewer endorsements of resource-costly altruistic attitudes. Empathic concern was positively correlated with endorsements of resource-costly altruistic attitudes. Taken together, our study provides direct evidence that the AI and alexithymia play crucial roles in everyday altruistic attitudes and reinforces the importance of the emotional experience in altruism.

Original languageEnglish (US)
Pages (from-to)428-439
Number of pages12
JournalNeuropsychologia
Volume117
DOIs
StatePublished - Aug 1 2018

Keywords

  • Alexithymia
  • Altruistic attitudes
  • Anterior insula
  • Voxel-based lesion-symptom mapping

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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