Anterior Corneal Disease of Epidermolysis Bullosa Simplex

Anthony P. Adamis, Oliver D Schein, Kenneth R. Kenyon

Research output: Contribution to journalArticle


We report the histopathological findings of the anterior cornea from a patient with skin biopsy-proven epidermolysis bullosa simplex. As seen with light microscopy, the cornea had a fibrocellular pannus deep to a thickened epithelial basement membrane. Transmission electron microscopy of the anterior cornea demonstrated a nonhomogeneous basal epithelial layer with abnormal attachment complexes to an irregular, multilaminar basement membrane. The findings of transmission electron microscopy of the bulbar conjunctiva were normal.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
JournalArchives of Ophthalmology
Issue number4
Publication statusPublished - 1993


ASJC Scopus subject areas

  • Ophthalmology

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