Antepartum and postpartum thrombomodulin levels in preeclamptic and normotensive pregnancies

Chaur Dong Hsu, Joshua A. Copel, Daniel W. Chan

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine whether changes in plasma levels of thrombomodulin from antepartum to postpartum reflect the postpartum regression of preeclampsia. METHODS: Twenty-four preeclamptic women and 34 healthy, normotensive women with singleton pregnancies were studied in the third trimester. Plasma levels of thrombomodulin in the antepartum and postpartum periods were measured by a two-site immunoenzymatic assay. Two- tailed Student t test and paired-comparison t test were used for statistical analyses. The results were expressed as mean ± standard error. RESULTS: Antepartum plasma thrombomodulin levels in preeclampsia were significantly higher than postpartum levels (71.3 ± 8.5 versus 55.5 ± 5.4 ng/mL; P = .006), which was not seen in the normotensive controls (49.9 ± 3.1 versus 44.2 ± 3.8 ng/mL; P > .05). Antepartum plasma levels of thrombomodulin in preeclampsia women were significantly higher than those in the normotensive controls (P = .01). However, postpartum plasma levels of thrombomodulin in preeclamptic women were not significantly higher than those in the normotensive controls (P > .05). CONCLUSION: Significantly decreased postpartum plasma thrombomodulin levels in preeclamptic pregnancies strongly correspond to clinical postpartum regression of preeclampsia.

Original languageEnglish (US)
Pages (from-to)135-137
Number of pages3
JournalJournal of the Society for Gynecologic Investigation
Volume4
Issue number3
DOIs
StatePublished - May 1 1997
Externally publishedYes

Keywords

  • Antepartum
  • Postpartum
  • Preeclampsia
  • Thrombomodulin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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