TY - JOUR
T1 - Antecedents of epilepsy and seizures among children born at extremely low gestational age
AU - on behalf of ELGAN Study Group
AU - Singh, Rachana
AU - Douglass, Laurie M.
AU - O’Shea, T. Michael
AU - Stafstrom, Carl E.
AU - Allred, Elizabeth N.
AU - Engelke, Stephen
AU - Shah, Bhavesh
AU - Leviton, Alan
AU - Hereen, Timothy C.
AU - Kuban, Karl C.K.
N1 - Funding Information:
Funding This study was supported by grants from the National Institute of Neurological Disorders and Stroke (5U01NS040069–05; 2R01NS040069 − 06A2), the National Institute of Child Health and Human Development (5P30HD018655–34), and the Office of the National Institutes of Health Director (1UG3OD023348–01).
Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Objective: To identify specific risk factors for epilepsy for individuals born extremely preterm. Study Design: In a prospective cohort study, at 10-year follow-up, children were classified as having epilepsy or seizures not associated with epilepsy. We evaluated for association of perinatal factors using time-oriented, multinomial logistic regression models. Results: Of the 888 children included in the study, 66 had epilepsy and 39 had seizures not associated with epilepsy. Epilepsy was associated with an indicator of low socioeconomic status, maternal gestational fever, early physiologic instability, postnatal exposure to hydrocortisone, cerebral white matter disease and severe bronchopulmonary dysplasia. Seizure without epilepsy was associated with indicators of placental infection and inflammation, and hypoxemia during the first 24 postnatal hours. Conclusions: In children born extremely preterm, epilepsy and seizures not associated with epilepsy have different risk profiles. Though both profiles included indicators of infection and inflammation, the profile of risk factors for epilepsy included multiple indicators of endogenous vulnerability.
AB - Objective: To identify specific risk factors for epilepsy for individuals born extremely preterm. Study Design: In a prospective cohort study, at 10-year follow-up, children were classified as having epilepsy or seizures not associated with epilepsy. We evaluated for association of perinatal factors using time-oriented, multinomial logistic regression models. Results: Of the 888 children included in the study, 66 had epilepsy and 39 had seizures not associated with epilepsy. Epilepsy was associated with an indicator of low socioeconomic status, maternal gestational fever, early physiologic instability, postnatal exposure to hydrocortisone, cerebral white matter disease and severe bronchopulmonary dysplasia. Seizure without epilepsy was associated with indicators of placental infection and inflammation, and hypoxemia during the first 24 postnatal hours. Conclusions: In children born extremely preterm, epilepsy and seizures not associated with epilepsy have different risk profiles. Though both profiles included indicators of infection and inflammation, the profile of risk factors for epilepsy included multiple indicators of endogenous vulnerability.
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U2 - 10.1038/s41372-019-0355-4
DO - 10.1038/s41372-019-0355-4
M3 - Article
C2 - 30918341
AN - SCOPUS:85063621635
VL - 39
SP - 774
EP - 783
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 6
ER -