Antagonists of integrin α(v)β3 inhibit retinal neovascularization in a murine model

Jose Luna, Takao Tobe, Shaker A. Mousa, Thomas M. Reilly, Peter A. Campochiaro

Research output: Contribution to journalArticle

Abstract

Integrin α(v)β3 is differentially expressed in angiogenic blood vessels in skin granulation tissue, and α(v)β3 antagonists inhibit angiogenesis in chick chorioallantoic membranes. In this study, we investigated the role of α(v)β3 in retinal neovascularization. There was no detectable signal for α(v)β3 by immunohistochemistry in normal human retina, but neovascular tissue removed from the surface of the retina of patients with diabetic retinopathy showed intense staining for α(v)β3 within the endothelial cells of new blood vessels. In a murine model of oxygen-induced ischemic retinopathy, there was intense staining for α(v)β3 in endothelial cells participating in neovascularization but no detectable staining in normal retinal blood vessels of adult mice. Synthetic peptides that bind α(v)β3 and perturb α(v)β3-mediated adhesion in vitro inhibited retinal neovascularization in the murine model when given by intraperitoneal or periocular injections. These data suggest that α(v)β3 antagonists may provide a useful adjunct for the treatment of retinal neovascularization.

Original languageEnglish (US)
Pages (from-to)563-573
Number of pages11
JournalLaboratory Investigation
Volume75
Issue number4
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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