Another explanation for apparent epistasis

Andrew R. Wood, Marcus A. Tuke, Mike A. Nalls, Dena G. Hernandez, Stefania Bandinelli, Andrew B. Singleton, David Melzer, Luigi Ferrucci, Timothy M. Frayling, Michael N. Weedon

Research output: Contribution to journalArticle

Abstract

Epistasis occurs when the effect of a genetic variant on a trait is dependent on genotypes of other variants elsewhere in the genome. Hemani et al. recently reported the detection and replication of many instances of epistasis between pairs of variants influencing gene expression levels in humans. Using whole-genome sequencing data from 450 individuals we strongly replicated many of the reported interactions but, in each case, a single third variant captured by our sequencing data could explain all of the apparent epistasis. Our results provide an alternative explanation for the apparent epistasis observed for gene expression in humans. There is a Reply to this Brief Communication Arising by Hemani, G. et al. Nature 514, http://dx.doi.org/10.1038/nature13692 (2014).

Original languageEnglish (US)
Pages (from-to)E3-E5
JournalNature
Volume514
Issue number7520
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

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Genome
Gene Expression
Genotype

ASJC Scopus subject areas

  • General

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Wood, A. R., Tuke, M. A., Nalls, M. A., Hernandez, D. G., Bandinelli, S., Singleton, A. B., ... Weedon, M. N. (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. https://doi.org/10.1038/nature13691

Another explanation for apparent epistasis. / Wood, Andrew R.; Tuke, Marcus A.; Nalls, Mike A.; Hernandez, Dena G.; Bandinelli, Stefania; Singleton, Andrew B.; Melzer, David; Ferrucci, Luigi; Frayling, Timothy M.; Weedon, Michael N.

In: Nature, Vol. 514, No. 7520, 01.10.2014, p. E3-E5.

Research output: Contribution to journalArticle

Wood, AR, Tuke, MA, Nalls, MA, Hernandez, DG, Bandinelli, S, Singleton, AB, Melzer, D, Ferrucci, L, Frayling, TM & Weedon, MN 2014, 'Another explanation for apparent epistasis', Nature, vol. 514, no. 7520, pp. E3-E5. https://doi.org/10.1038/nature13691
Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB et al. Another explanation for apparent epistasis. Nature. 2014 Oct 1;514(7520):E3-E5. https://doi.org/10.1038/nature13691
Wood, Andrew R. ; Tuke, Marcus A. ; Nalls, Mike A. ; Hernandez, Dena G. ; Bandinelli, Stefania ; Singleton, Andrew B. ; Melzer, David ; Ferrucci, Luigi ; Frayling, Timothy M. ; Weedon, Michael N. / Another explanation for apparent epistasis. In: Nature. 2014 ; Vol. 514, No. 7520. pp. E3-E5.
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