Anopheles midgut FREP1 mediates plasmodium invasion

Genwei Zhang, Guodong Niu, Caio M. Franca, Yuemei Dong, Xiaohong Wang, Noah S. Butler, George Dimopoulos, Jun Li

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The molecular mechanisms of Plasmodium invasion in mosquito midguts are not well understood. Results: The mosquito midgut peritrophic matrix protein FREP1 binds Plasmodia. Blocking parasite-FREP1 interactions or ablating FREP1 expression reduced P. falciparum infection in mosquitoes. Conclusion: FREP1 functions as a critical host factor that mediates Plasmodium invasion in mosquito midguts. Significance: Targeting FREP1 may inhibit Plasmodium transmission to mosquitoes and the spread of malaria.

Original languageEnglish (US)
Pages (from-to)16490-16501
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
StatePublished - Jul 3 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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