Anomalous growth of rat incisor teeth during chronic intermittent vitamin a deficiency

E. M. McDowell, R. L. Shores, E. F. Spangler, M. L. Wenk, Luigi M De Luca

Research output: Contribution to journalArticle

Abstract

Rapid, synchronous and repeating cycles of marginal retinoic acid sufficiency and deficiency were produced in rats by following an established protocol. During cycles 11-15 (343-464 days after weaning), 17 of 24 rats (71%) developed tumor-like masses in the connective tissue surrounding the formative ends of one or both upper incisor teeth. The masses were composed of cords of odontogenic epithelium surrounded by a mantle of mesenchyme. Lakes of predentine, associated with foci of keratinized epithelium, were randomly distributed. On the basis of current understanding of odontogenesis, we propose that periodically disturbed differentiation of pulpal mesenchymal cells to dentin-secreting odontoblasts was pivotal to development of the masses. During deficiency, dentin secretion is impaired, the dentine wall perforates and with time the odontogenic epithelium and pulp herniate into the surrounding connective tissues. We propose that the incisal masses arose because the pulpal mesenchyme continued to grow and its secretion product, dentine, continued to be deposited (during periods of vitamin A sufficiency) in an ectopic site where functional attrition from mastication could not occur.

Original languageEnglish (US)
Pages (from-to)1265-1274
Number of pages10
JournalJournal of Nutrition
Volume117
Issue number7
StatePublished - 1987
Externally publishedYes

Fingerprint

vitamin deficiencies
Avitaminosis
Dentin
Incisor
Tooth
teeth
Epithelium
rats
Mesoderm
Growth
epithelium
Connective Tissue
Odontogenesis
connective tissues
Odontoblasts
secretion
Mastication
Lakes
Tretinoin
Weaning

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

McDowell, E. M., Shores, R. L., Spangler, E. F., Wenk, M. L., & De Luca, L. M. (1987). Anomalous growth of rat incisor teeth during chronic intermittent vitamin a deficiency. Journal of Nutrition, 117(7), 1265-1274.

Anomalous growth of rat incisor teeth during chronic intermittent vitamin a deficiency. / McDowell, E. M.; Shores, R. L.; Spangler, E. F.; Wenk, M. L.; De Luca, Luigi M.

In: Journal of Nutrition, Vol. 117, No. 7, 1987, p. 1265-1274.

Research output: Contribution to journalArticle

McDowell, EM, Shores, RL, Spangler, EF, Wenk, ML & De Luca, LM 1987, 'Anomalous growth of rat incisor teeth during chronic intermittent vitamin a deficiency', Journal of Nutrition, vol. 117, no. 7, pp. 1265-1274.
McDowell, E. M. ; Shores, R. L. ; Spangler, E. F. ; Wenk, M. L. ; De Luca, Luigi M. / Anomalous growth of rat incisor teeth during chronic intermittent vitamin a deficiency. In: Journal of Nutrition. 1987 ; Vol. 117, No. 7. pp. 1265-1274.
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