Abstract
Objectives: Attention-deficit/hyperactivity disorder (ADHD) is a common neurological disorder with symptom onset early in childhood. Growing evidence suggests anomalous brain development across multiple brain regions is evident in school-aged children; however, few studies have examined whether such differences are notable in the preschool years when symptom onset typically occurs. Methods: High resolution anatomical (MPRAGE) images and cognitive and behavioral measures were analyzed in a total of 90 medication-naïve preschoolers, ages 4–5 years (52 with ADHD, 38 controls; 64.4% boys). Results: Results revealed reductions in bilateral frontal, parietal, and temporal lobe gray matter volumes in children with ADHD relative to typically developing children, with largest effect sizes noted for right frontal and left temporal lobe volumes. Examining frontal lobe sub-regions, the largest between group effect sizes were evident for left orbitofrontal cortex, left primary motor cortex (M1), and left supplementary motor complex (SMC). ADHD-related reductions in specific sub-regions (left prefrontal, left premotor, left frontal eye field, left M1, and right SMC) were significantly correlated with symptom severity, such that higher ratings of hyperactive/impulsive symptoms were associated with reduced cortical volumes. Conclusions: These findings represent the first comprehensive examination of cortical volume in preschool children with ADHD, providing evidence that anomalous brain structure in ADHD is evident very early in development. Furthermore, findings set the stage for developing our understanding of the way in which developmental trajectories of anomalous brain development are associated with the unfolding of symptoms in childhood ADHD. (JINS, 2018, 24, 1–9)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Journal of the International Neuropsychological Society |
| DOIs | |
| State | Accepted/In press - Mar 26 2018 |
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Keywords
- Attention
- Behavior rating scale
- Children
- Cognitive functioning
- Developmental disabilities
- Magnetic resonance imaging
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Psychology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Anomalous Brain Development Is Evident in Preschoolers With Attention-Deficit/Hyperactivity Disorder. / Jacobson, Lisa Anne; Crocetti, Deana; Dirlikov, Benjamin; Slifer, Keith John; Denckla, Martha Bridge; Mostofsky, Stewart H; Mahone, Ernest M.
In: Journal of the International Neuropsychological Society, 26.03.2018, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anomalous Brain Development Is Evident in Preschoolers With Attention-Deficit/Hyperactivity Disorder
AU - Jacobson, Lisa Anne
AU - Crocetti, Deana
AU - Dirlikov, Benjamin
AU - Slifer, Keith John
AU - Denckla, Martha Bridge
AU - Mostofsky, Stewart H
AU - Mahone, Ernest M
PY - 2018/3/26
Y1 - 2018/3/26
N2 - Objectives: Attention-deficit/hyperactivity disorder (ADHD) is a common neurological disorder with symptom onset early in childhood. Growing evidence suggests anomalous brain development across multiple brain regions is evident in school-aged children; however, few studies have examined whether such differences are notable in the preschool years when symptom onset typically occurs. Methods: High resolution anatomical (MPRAGE) images and cognitive and behavioral measures were analyzed in a total of 90 medication-naïve preschoolers, ages 4–5 years (52 with ADHD, 38 controls; 64.4% boys). Results: Results revealed reductions in bilateral frontal, parietal, and temporal lobe gray matter volumes in children with ADHD relative to typically developing children, with largest effect sizes noted for right frontal and left temporal lobe volumes. Examining frontal lobe sub-regions, the largest between group effect sizes were evident for left orbitofrontal cortex, left primary motor cortex (M1), and left supplementary motor complex (SMC). ADHD-related reductions in specific sub-regions (left prefrontal, left premotor, left frontal eye field, left M1, and right SMC) were significantly correlated with symptom severity, such that higher ratings of hyperactive/impulsive symptoms were associated with reduced cortical volumes. Conclusions: These findings represent the first comprehensive examination of cortical volume in preschool children with ADHD, providing evidence that anomalous brain structure in ADHD is evident very early in development. Furthermore, findings set the stage for developing our understanding of the way in which developmental trajectories of anomalous brain development are associated with the unfolding of symptoms in childhood ADHD. (JINS, 2018, 24, 1–9)
AB - Objectives: Attention-deficit/hyperactivity disorder (ADHD) is a common neurological disorder with symptom onset early in childhood. Growing evidence suggests anomalous brain development across multiple brain regions is evident in school-aged children; however, few studies have examined whether such differences are notable in the preschool years when symptom onset typically occurs. Methods: High resolution anatomical (MPRAGE) images and cognitive and behavioral measures were analyzed in a total of 90 medication-naïve preschoolers, ages 4–5 years (52 with ADHD, 38 controls; 64.4% boys). Results: Results revealed reductions in bilateral frontal, parietal, and temporal lobe gray matter volumes in children with ADHD relative to typically developing children, with largest effect sizes noted for right frontal and left temporal lobe volumes. Examining frontal lobe sub-regions, the largest between group effect sizes were evident for left orbitofrontal cortex, left primary motor cortex (M1), and left supplementary motor complex (SMC). ADHD-related reductions in specific sub-regions (left prefrontal, left premotor, left frontal eye field, left M1, and right SMC) were significantly correlated with symptom severity, such that higher ratings of hyperactive/impulsive symptoms were associated with reduced cortical volumes. Conclusions: These findings represent the first comprehensive examination of cortical volume in preschool children with ADHD, providing evidence that anomalous brain structure in ADHD is evident very early in development. Furthermore, findings set the stage for developing our understanding of the way in which developmental trajectories of anomalous brain development are associated with the unfolding of symptoms in childhood ADHD. (JINS, 2018, 24, 1–9)
KW - Attention
KW - Behavior rating scale
KW - Children
KW - Cognitive functioning
KW - Developmental disabilities
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85044390259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044390259&partnerID=8YFLogxK
U2 - 10.1017/S1355617718000103
DO - 10.1017/S1355617718000103
M3 - Article
C2 - 29576028
AN - SCOPUS:85044390259
SP - 1
EP - 9
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
SN - 1355-6177
ER -