Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant.

A. E. Good; J. T. Cassidy; M. G. Mutchnick; R. E. Reed; H. M. Lederman

Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant.

A. E. Good, J. T. Cassidy, M. G. Mutchnick, R. E. Reed, H. M. Lederman

Research output: Contribution to journal › Article › peer-review

Abstract

A patient with ankylosing spondylitis was found to have selective IgA deficiency and a non-heparin, immediate-acting antithrombin (antithrombin V). T cells were decreased, and serum IgG was increased. In vitro synthesis of IgG by peripheral blood lymphocytes was very high. This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA.

Original language	English (US)
Pages (from-to)	297-302
Number of pages	6
Journal	Journal of Rheumatology
Volume	4
Issue number	3
State	Published - Sep 1 1977
Externally published	Yes

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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abstract = "A patient with ankylosing spondylitis was found to have selective IgA deficiency and a non-heparin, immediate-acting antithrombin (antithrombin V). T cells were decreased, and serum IgG was increased. In vitro synthesis of IgG by peripheral blood lymphocytes was very high. This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA.",

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AU - Good, A. E.

AU - Cassidy, J. T.

AU - Mutchnick, M. G.

AU - Reed, R. E.

AU - Lederman, H. M.

PY - 1977/9/1

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N2 - A patient with ankylosing spondylitis was found to have selective IgA deficiency and a non-heparin, immediate-acting antithrombin (antithrombin V). T cells were decreased, and serum IgG was increased. In vitro synthesis of IgG by peripheral blood lymphocytes was very high. This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA.

AB - A patient with ankylosing spondylitis was found to have selective IgA deficiency and a non-heparin, immediate-acting antithrombin (antithrombin V). T cells were decreased, and serum IgG was increased. In vitro synthesis of IgG by peripheral blood lymphocytes was very high. This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA.

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JF - Journal of Rheumatology

IS - 3

ER -

Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant.

Abstract

ASJC Scopus subject areas

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