TY - JOUR
T1 - Ankylosing spondylitis
T2 - etiology, pathogenesis, and treatments
AU - Zhu, Wei
AU - He, Xuxia
AU - Cheng, Kaiyuan
AU - Zhang, Linjie
AU - Chen, Di
AU - Wang, Xiao
AU - Qiu, Guixing
AU - Cao, Xu
AU - Weng, Xisheng
N1 - Funding Information:
This work was supported by the Beijing Natural Science Foundation youth project (7184325) and the China Postdoctoral Foundation NO.62 general program.
Publisher Copyright:
© 2019, The Author(s).
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.
AB - Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.
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U2 - 10.1038/s41413-019-0057-8
DO - 10.1038/s41413-019-0057-8
M3 - Review article
C2 - 31666997
AN - SCOPUS:85070207607
VL - 7
JO - Bone Research
JF - Bone Research
SN - 2095-4700
IS - 1
M1 - 22
ER -