Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study

Anne B. Newman, Lynn Shemanski, Teri A. Manolio, Mary Cushman, Maurice Mittelmark, Joseph F. Polak, Neil R. Powe, David Siscovick

Research output: Contribution to journalArticle

Abstract

Peripheral arterial disease (PAD) in the legs, measured noninvasively by the ankle-arm index (AAI) is associated with clinically manifest cardiovascular disease (CVD) and its risk factors. To determine risk of total mortality, coronary heart disease, or Stroke mortality and incident versus recurrent CVD associated with a low AAI, we examined the relationship of the AAI to subsequent CVD events in 5888 older adults with and without CVD. The AAI was measured in 5888 participants ≥65 years old at the baseline examination of the Cardiovascular Health Study. All participants had a detailed assessment of prevalent CVD and were contacted every 6 months for total mortality and CVD events (including CVD mortality, fatal and nonfatal myocardial infarction, congestive heart failure, angina, stroke, and hospitalized PAD). The crude mortality rate at 6 years was highest (32.3%) in those participants with prevalent CVD and a low AAI (P

Original languageEnglish (US)
Pages (from-to)538-545
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume19
Issue number3
StatePublished - Mar 1999

Fingerprint

Ankle
Arm
Cardiovascular Diseases
Mortality
Health
Peripheral Arterial Disease
Stroke
Coronary Disease
Leg
Heart Failure
Myocardial Infarction

Keywords

  • Ankle-arm index
  • Ankle-brachial pressure index
  • Cardiovascular diseases, epidemiology
  • Peripheral vascular diseases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Newman, A. B., Shemanski, L., Manolio, T. A., Cushman, M., Mittelmark, M., Polak, J. F., ... Siscovick, D. (1999). Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 19(3), 538-545.

Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. / Newman, Anne B.; Shemanski, Lynn; Manolio, Teri A.; Cushman, Mary; Mittelmark, Maurice; Polak, Joseph F.; Powe, Neil R.; Siscovick, David.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 19, No. 3, 03.1999, p. 538-545.

Research output: Contribution to journalArticle

Newman, AB, Shemanski, L, Manolio, TA, Cushman, M, Mittelmark, M, Polak, JF, Powe, NR & Siscovick, D 1999, 'Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 3, pp. 538-545.
Newman AB, Shemanski L, Manolio TA, Cushman M, Mittelmark M, Polak JF et al. Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1999 Mar;19(3):538-545.
Newman, Anne B. ; Shemanski, Lynn ; Manolio, Teri A. ; Cushman, Mary ; Mittelmark, Maurice ; Polak, Joseph F. ; Powe, Neil R. ; Siscovick, David. / Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1999 ; Vol. 19, No. 3. pp. 538-545.
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