Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study

Anne B. Newman, David S. Siscovick, Teri A. Manolio, Joseph Polak, Linda P Fried, Nemat O. Borhani, Sidney K. Wolfson

Research output: Contribution to journalArticle

Abstract

Background. Peripheral arterial disease measured noninvasively by the ankle-arm index (AAI) is common in older adults, largely asymptomatic, and associated with clinically manifest cardiovascular disease (CVD). The criteria for an abnormal AAI have varied in previous studies. To determine whether there is an inverse dose-response relation between the AAI and clinical CVD, subclinical disease, and risk factors, we examined the relation of the AAI to cardiovascular risk factors, other noninvasive measures of subclinical atherosclerosis using carotid ultrasound, echocardiography and electrocardiography, and clinical CVD. Methods and Results. The AAI was measured in 5084 participants ≥65 years old at the baseline examination of the Cardiovascular Health Study. All subjects had detailed assessment of prevalent CVD, measures of cardiovascular risk factors, and noninvasive measures of disease. Participants were stratified by baseline clinical CVD status and AAI (

Original languageEnglish (US)
Pages (from-to)837-845
Number of pages9
JournalCirculation
Volume88
Issue number3
StatePublished - Sep 1993

Fingerprint

Ankle
Atherosclerosis
Arm
Cardiovascular Diseases
Health
Carotid Artery Diseases
Peripheral Arterial Disease
Echocardiography
Electrocardiography

Keywords

  • Aging
  • Epidemiology
  • Peripheral vasculature
  • Tests

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Newman, A. B., Siscovick, D. S., Manolio, T. A., Polak, J., Fried, L. P., Borhani, N. O., & Wolfson, S. K. (1993). Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study. Circulation, 88(3), 837-845.

Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study. / Newman, Anne B.; Siscovick, David S.; Manolio, Teri A.; Polak, Joseph; Fried, Linda P; Borhani, Nemat O.; Wolfson, Sidney K.

In: Circulation, Vol. 88, No. 3, 09.1993, p. 837-845.

Research output: Contribution to journalArticle

Newman, AB, Siscovick, DS, Manolio, TA, Polak, J, Fried, LP, Borhani, NO & Wolfson, SK 1993, 'Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study', Circulation, vol. 88, no. 3, pp. 837-845.
Newman AB, Siscovick DS, Manolio TA, Polak J, Fried LP, Borhani NO et al. Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study. Circulation. 1993 Sep;88(3):837-845.
Newman, Anne B. ; Siscovick, David S. ; Manolio, Teri A. ; Polak, Joseph ; Fried, Linda P ; Borhani, Nemat O. ; Wolfson, Sidney K. / Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study. In: Circulation. 1993 ; Vol. 88, No. 3. pp. 837-845.
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