Animal toxins influence voltage-gated sodium channel function

John Gilchrist; Baldomero M. Olivera; Frank Bosmans

doi:10.1007/978-3-642-41588-3_10

Animal toxins influence voltage-gated sodium channel function

John Gilchrist, Baldomero M. Olivera, Frank Bosmans

School of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability, making them the most commonly targeted ion channel family by toxins found in animal venoms. These molecules can be used to probe the functional aspects of Nav channels on a molecular level and to explore their physiological role in normal and diseased tissues. This chapter summarizes our existing knowledge of the mechanisms by which animal toxins influence Nav channels as well as their potential application in designing therapeutic drugs.

Original language	English (US)
Pages (from-to)	203-229
Number of pages	27
Journal	Handbook of Experimental Pharmacology
Volume	221
DOIs	https://doi.org/10.1007/978-3-642-41588-3_10
State	Published - 2014

Keywords

Animal toxin
Gating-modifier
Pore-blocker
Sodium channel
Venom

ASJC Scopus subject areas

Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/978-3-642-41588-3_10

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abstract = "Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability, making them the most commonly targeted ion channel family by toxins found in animal venoms. These molecules can be used to probe the functional aspects of Nav channels on a molecular level and to explore their physiological role in normal and diseased tissues. This chapter summarizes our existing knowledge of the mechanisms by which animal toxins influence Nav channels as well as their potential application in designing therapeutic drugs.",

keywords = "Animal toxin, Gating-modifier, Pore-blocker, Sodium channel, Venom",

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AU - Bosmans, Frank

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Y1 - 2014

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AB - Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability, making them the most commonly targeted ion channel family by toxins found in animal venoms. These molecules can be used to probe the functional aspects of Nav channels on a molecular level and to explore their physiological role in normal and diseased tissues. This chapter summarizes our existing knowledge of the mechanisms by which animal toxins influence Nav channels as well as their potential application in designing therapeutic drugs.

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KW - Gating-modifier

KW - Pore-blocker

KW - Sodium channel

KW - Venom

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Animal toxins influence voltage-gated sodium channel function

Abstract

Keywords

ASJC Scopus subject areas

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