Animal toxins influence voltage-gated sodium channel function

John Gilchrist, Baldomero M. Olivera, Frank Bosmans

Research output: Contribution to journalArticlepeer-review

Abstract

Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability, making them the most commonly targeted ion channel family by toxins found in animal venoms. These molecules can be used to probe the functional aspects of Nav channels on a molecular level and to explore their physiological role in normal and diseased tissues. This chapter summarizes our existing knowledge of the mechanisms by which animal toxins influence Nav channels as well as their potential application in designing therapeutic drugs.

Original languageEnglish (US)
Pages (from-to)203-229
Number of pages27
JournalHandbook of Experimental Pharmacology
Volume221
DOIs
StatePublished - 2014

Keywords

  • Animal toxin
  • Gating-modifier
  • Pore-blocker
  • Sodium channel
  • Venom

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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