Animal toxins can alter the function of Nav1.8 and Nav1.9

John Gilchrist, Frank bosmans

Research output: Contribution to journalArticle

Abstract

Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine isoforms, Nav1.8 and Nav1.9 are preferentially expressed in DRG neurons where they are thought to play an important role in pain signaling. Although the functional properties of Nav1.8 have been relatively well characterized, difficulties with expressing Nav1.9 in established heterologous systems limit our understanding of the gating properties and toxin pharmacology of this particular isoform. This review summarizes our current knowledge of the role of Nav1.8 and Nav1.9 in pain perception and elaborates on the approaches used to identify molecules capable of influencing their function.

Original languageEnglish (US)
Pages (from-to)620-632
Number of pages13
JournalToxins
Volume4
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Protein Isoforms
Animals
Pain Perception
Sodium Channels
Diagnosis-Related Groups
Ion Channels
Neurons
Pharmacology
Tissue
Pain
Molecules
Electric potential
Pharmaceutical Preparations
icodextrin

Keywords

  • Animal toxins
  • Nav1.8
  • Nav1.9
  • Pain
  • Voltage sensor
  • Voltage-activated sodium channel

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Animal toxins can alter the function of Nav1.8 and Nav1.9. / Gilchrist, John; bosmans, Frank.

In: Toxins, Vol. 4, No. 8, 08.2012, p. 620-632.

Research output: Contribution to journalArticle

Gilchrist, John ; bosmans, Frank. / Animal toxins can alter the function of Nav1.8 and Nav1.9. In: Toxins. 2012 ; Vol. 4, No. 8. pp. 620-632.
@article{73c98b0a8985402e85fe1f00cd6ce561,
title = "Animal toxins can alter the function of Nav1.8 and Nav1.9",
abstract = "Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine isoforms, Nav1.8 and Nav1.9 are preferentially expressed in DRG neurons where they are thought to play an important role in pain signaling. Although the functional properties of Nav1.8 have been relatively well characterized, difficulties with expressing Nav1.9 in established heterologous systems limit our understanding of the gating properties and toxin pharmacology of this particular isoform. This review summarizes our current knowledge of the role of Nav1.8 and Nav1.9 in pain perception and elaborates on the approaches used to identify molecules capable of influencing their function.",
keywords = "Animal toxins, Nav1.8, Nav1.9, Pain, Voltage sensor, Voltage-activated sodium channel",
author = "John Gilchrist and Frank bosmans",
year = "2012",
month = "8",
doi = "10.3 3 90/toxins4080620",
language = "English (US)",
volume = "4",
pages = "620--632",
journal = "Toxins",
issn = "2072-6651",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

TY - JOUR

T1 - Animal toxins can alter the function of Nav1.8 and Nav1.9

AU - Gilchrist, John

AU - bosmans, Frank

PY - 2012/8

Y1 - 2012/8

N2 - Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine isoforms, Nav1.8 and Nav1.9 are preferentially expressed in DRG neurons where they are thought to play an important role in pain signaling. Although the functional properties of Nav1.8 have been relatively well characterized, difficulties with expressing Nav1.9 in established heterologous systems limit our understanding of the gating properties and toxin pharmacology of this particular isoform. This review summarizes our current knowledge of the role of Nav1.8 and Nav1.9 in pain perception and elaborates on the approaches used to identify molecules capable of influencing their function.

AB - Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine isoforms, Nav1.8 and Nav1.9 are preferentially expressed in DRG neurons where they are thought to play an important role in pain signaling. Although the functional properties of Nav1.8 have been relatively well characterized, difficulties with expressing Nav1.9 in established heterologous systems limit our understanding of the gating properties and toxin pharmacology of this particular isoform. This review summarizes our current knowledge of the role of Nav1.8 and Nav1.9 in pain perception and elaborates on the approaches used to identify molecules capable of influencing their function.

KW - Animal toxins

KW - Nav1.8

KW - Nav1.9

KW - Pain

KW - Voltage sensor

KW - Voltage-activated sodium channel

UR - http://www.scopus.com/inward/record.url?scp=84865402118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865402118&partnerID=8YFLogxK

U2 - 10.3 3 90/toxins4080620

DO - 10.3 3 90/toxins4080620

M3 - Article

C2 - 23012651

AN - SCOPUS:84865402118

VL - 4

SP - 620

EP - 632

JO - Toxins

JF - Toxins

SN - 2072-6651

IS - 8

ER -