Animal Models of the Hormone-sensitive and-insensitive Prostatic Adenocarcinomas, Dunning R-332T-H, R-3327-HI, and R-3327-AT

John T. Isaacs, Warren D.W. Heston, Robert M. Weissman, Donald S. Coffey

Research output: Contribution to journalArticlepeer-review

Abstract

The Dunning R-3327-H is a well-differentiated transplantable rat prostatic adenocarcinoma that contains both hormone-sensitive and-insensitive cells. The component composed of hormone-insensitive cells has been permitted to grow in a castrated male, and a new slow-growing, well-differentiated hormone-insensitive subline of the tumor has been established and designated R-3327-HI. In addition, a rapidly growing hormone-insensitive anaplastic tumor has been developed, R-3327-AT. These three tumor lines have been characterized, and their histological and biochemical profiles are compared.

Original languageEnglish (US)
Pages (from-to)4353-4359
Number of pages7
JournalCancer Research
Volume38
StatePublished - Nov 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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