Animal models of memory impairment

Research output: Contribution to journalArticle

Abstract

Memory impairment in the elderly resembles a mild temporal lobe dysfunction. Alterations in the hippocampal formation are also a probable basis for cognitive deficits in some animal models of ageing. For example, aged rats are impaired in hippocampal-dependent tests of spatial memory. Recent studies have revealed considerable structural integrity in the aged hippocampus, even in aged rats with the most impaired spatial memory. In contrast, atrophy/loss of cholinergic neurons in the basal forebrain and deficiency in cholinergic transduction in hippocampus correlate with the severity of spatial memory impairment in aged rats. This evidence supports the longstanding view that age-related loss of memory has a cholinergic basis. In this context, it is somewhat surprising that the use of a selective cholinergic immunotoxin in young rats to further test this hypothesis has revealed normal spatial memory after removing septo-hippocampal cholinergic neurons. Young rats with immunotoxic lesions, however, have other behavioural impairments in tests of attentional processing. These lines of research have implications for understanding the neurobiological basis of memory deficits in ageing and for selecting an optimal behavioural setting in which to examine therapies aimed at restoring neurobiological function.

Original languageEnglish (US)
Pages (from-to)1711-1717
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume352
Issue number1362
DOIs
StatePublished - Nov 29 1997
Externally publishedYes

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Animals
cholinergic agents
Animal Models
animal models
Cholinergic Agents
Data storage equipment
Rats
animal
Hippocampus
Cholinergic Neurons
hippocampus
Memory Disorders
rats
Immunotoxins
Neurons
Aging of materials
neurons
Temporal Lobe
Atrophy
testing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Animal models of memory impairment. / Gallagher, Michela.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 352, No. 1362, 29.11.1997, p. 1711-1717.

Research output: Contribution to journalArticle

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