Animal models of glaucoma

Rachida A. Bouhenni, Jeffrey Dunmire, Abby Sewell, Deepak P. Edward

Research output: Contribution to journalArticle

Abstract

Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of blindness and visual impairment worldwide. Although research in the field of glaucoma is substantial, the pathophysiologic mechanisms causing the disease are not completely understood. A wide variety of animal models have been used to study glaucoma. These include monkeys, dogs, cats, rodents, and several other species. Although these models have provided valuable information about the disease, there is still no ideal model for studying glaucoma due to its complexity. In this paper we present a summary of most of the animal models that have been developed and used for the study of the different types of glaucoma, the strengths and limitations associated with each species use, and some potential criteria to develop a suitable model.

Original languageEnglish (US)
Article number692609
JournalJournal of Biomedicine and Biotechnology
Volume2012
DOIs
StatePublished - 2012

Fingerprint

Glaucoma
Animals
Animal Models
Blindness
Retinal Ganglion Cells
Vision Disorders
Optic Nerve
Haplorhini
Rodentia
Optics
Cats
Dogs
Research

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis

Cite this

Bouhenni, R. A., Dunmire, J., Sewell, A., & Edward, D. P. (2012). Animal models of glaucoma. Journal of Biomedicine and Biotechnology, 2012, [692609]. https://doi.org/10.1155/2012/692609

Animal models of glaucoma. / Bouhenni, Rachida A.; Dunmire, Jeffrey; Sewell, Abby; Edward, Deepak P.

In: Journal of Biomedicine and Biotechnology, Vol. 2012, 692609, 2012.

Research output: Contribution to journalArticle

Bouhenni, RA, Dunmire, J, Sewell, A & Edward, DP 2012, 'Animal models of glaucoma', Journal of Biomedicine and Biotechnology, vol. 2012, 692609. https://doi.org/10.1155/2012/692609
Bouhenni RA, Dunmire J, Sewell A, Edward DP. Animal models of glaucoma. Journal of Biomedicine and Biotechnology. 2012;2012. 692609. https://doi.org/10.1155/2012/692609
Bouhenni, Rachida A. ; Dunmire, Jeffrey ; Sewell, Abby ; Edward, Deepak P. / Animal models of glaucoma. In: Journal of Biomedicine and Biotechnology. 2012 ; Vol. 2012.
@article{2f82f24cfbe143bfa5840df937211cee,
title = "Animal models of glaucoma",
abstract = "Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of blindness and visual impairment worldwide. Although research in the field of glaucoma is substantial, the pathophysiologic mechanisms causing the disease are not completely understood. A wide variety of animal models have been used to study glaucoma. These include monkeys, dogs, cats, rodents, and several other species. Although these models have provided valuable information about the disease, there is still no ideal model for studying glaucoma due to its complexity. In this paper we present a summary of most of the animal models that have been developed and used for the study of the different types of glaucoma, the strengths and limitations associated with each species use, and some potential criteria to develop a suitable model.",
author = "Bouhenni, {Rachida A.} and Jeffrey Dunmire and Abby Sewell and Edward, {Deepak P.}",
year = "2012",
doi = "10.1155/2012/692609",
language = "English (US)",
volume = "2012",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Animal models of glaucoma

AU - Bouhenni, Rachida A.

AU - Dunmire, Jeffrey

AU - Sewell, Abby

AU - Edward, Deepak P.

PY - 2012

Y1 - 2012

N2 - Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of blindness and visual impairment worldwide. Although research in the field of glaucoma is substantial, the pathophysiologic mechanisms causing the disease are not completely understood. A wide variety of animal models have been used to study glaucoma. These include monkeys, dogs, cats, rodents, and several other species. Although these models have provided valuable information about the disease, there is still no ideal model for studying glaucoma due to its complexity. In this paper we present a summary of most of the animal models that have been developed and used for the study of the different types of glaucoma, the strengths and limitations associated with each species use, and some potential criteria to develop a suitable model.

AB - Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of blindness and visual impairment worldwide. Although research in the field of glaucoma is substantial, the pathophysiologic mechanisms causing the disease are not completely understood. A wide variety of animal models have been used to study glaucoma. These include monkeys, dogs, cats, rodents, and several other species. Although these models have provided valuable information about the disease, there is still no ideal model for studying glaucoma due to its complexity. In this paper we present a summary of most of the animal models that have been developed and used for the study of the different types of glaucoma, the strengths and limitations associated with each species use, and some potential criteria to develop a suitable model.

UR - http://www.scopus.com/inward/record.url?scp=84862279406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862279406&partnerID=8YFLogxK

U2 - 10.1155/2012/692609

DO - 10.1155/2012/692609

M3 - Article

C2 - 22665989

AN - SCOPUS:84862279406

VL - 2012

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 692609

ER -