TY - JOUR
T1 - Animal models of gene-environment interaction in schizophrenia
T2 - A dimensional perspective
AU - Ayhan, Yavuz
AU - McFarland, Ross
AU - Pletnikov, Mikhail V.
N1 - Funding Information:
We thank the following funding agencies for the support: MH-083728, MH-094268 Silvio O. Conte Center and the Brain and Behavior Research Foundation (MVP) .
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Schizophrenia has long been considered as a disorder with multifactorial origins. Recent discoveries have advanced our understanding of the genetic architecture of the disease. However, even with the increase of identified risk variants, heritability estimates suggest an important contribution of non-genetic factors. Various environmental risk factors have been proposed to play a role in the etiopathogenesis of schizophrenia. These include season of birth, maternal infections, obstetric complications, adverse events at early childhood, and drug abuse. Despite the progress in identification of genetic and environmental risk factors, we still have a limited understanding of the mechanisms whereby gene-environment interactions (G × E) operate in schizophrenia and psychoses at large. In this review we provide a critical analysis of current animal models of G × E relevant to psychotic disorders and propose that dimensional perspective will advance our understanding of the complex mechanisms of these disorders.
AB - Schizophrenia has long been considered as a disorder with multifactorial origins. Recent discoveries have advanced our understanding of the genetic architecture of the disease. However, even with the increase of identified risk variants, heritability estimates suggest an important contribution of non-genetic factors. Various environmental risk factors have been proposed to play a role in the etiopathogenesis of schizophrenia. These include season of birth, maternal infections, obstetric complications, adverse events at early childhood, and drug abuse. Despite the progress in identification of genetic and environmental risk factors, we still have a limited understanding of the mechanisms whereby gene-environment interactions (G × E) operate in schizophrenia and psychoses at large. In this review we provide a critical analysis of current animal models of G × E relevant to psychotic disorders and propose that dimensional perspective will advance our understanding of the complex mechanisms of these disorders.
KW - Animal models
KW - Dimensional perspective
KW - Psychotic disorders
KW - RDoC
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U2 - 10.1016/j.pneurobio.2015.10.002
DO - 10.1016/j.pneurobio.2015.10.002
M3 - Review article
C2 - 26510407
AN - SCOPUS:84951912775
VL - 136
SP - 1
EP - 27
JO - Progress in Neurobiology
JF - Progress in Neurobiology
SN - 0301-0082
ER -