Animal Models of Enterovirus D68 Infection and Disease

Meghan S. Vermillion; Justin Dearing; Yun Zhang; Danielle R. Adney; Richard H. Scheuermann; Andrew Pekosz; E. Bart Tarbet

doi:10.1128/jvi.00833-22

Animal Models of Enterovirus D68 Infection and Disease

Meghan S. Vermillion, Justin Dearing, Yun Zhang, Danielle R. Adney, Richard H. Scheuermann, Andrew Pekosz, E. Bart Tarbet

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in children. Currently, there are no approved vaccines or treatments for EV-D68 infection, and there is a paucity of data related to the virus and host-specific factors that predict disease severity and progression to the neurologic syndrome. EV-D68 infection of various animal models has served as an important platform for characterization and comparison of disease pathogenesis between historic and contemporary isolates. Still, there are significant gaps in our knowledge of EV-D68 pathogenesis that constrain the development and evaluation of targeted vaccines and antiviral therapies. Continued refinement and characterization of animal models that faithfully reproduce key elements of EV-D68 infection and disease is essential for ensuring public health preparedness for future EV-D68 outbreaks.

Original language	English (US)
Journal	Journal of virology
Volume	96
Issue number	15
DOIs	https://doi.org/10.1128/jvi.00833-22
State	Published - Aug 2022

Keywords

AFM
EV-D68
acute flaccid myelitis
non-polio enterovirus
respiratory enterovirus

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.00833-22

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title = "Animal Models of Enterovirus D68 Infection and Disease",

abstract = "Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in children. Currently, there are no approved vaccines or treatments for EV-D68 infection, and there is a paucity of data related to the virus and host-specific factors that predict disease severity and progression to the neurologic syndrome. EV-D68 infection of various animal models has served as an important platform for characterization and comparison of disease pathogenesis between historic and contemporary isolates. Still, there are significant gaps in our knowledge of EV-D68 pathogenesis that constrain the development and evaluation of targeted vaccines and antiviral therapies. Continued refinement and characterization of animal models that faithfully reproduce key elements of EV-D68 infection and disease is essential for ensuring public health preparedness for future EV-D68 outbreaks.",

keywords = "AFM, EV-D68, acute flaccid myelitis, non-polio enterovirus, respiratory enterovirus",

author = "Vermillion, {Meghan S.} and Justin Dearing and Yun Zhang and Adney, {Danielle R.} and Scheuermann, {Richard H.} and Andrew Pekosz and {Bart Tarbet}, E.",

note = "Funding Information: This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contracts HHSN272201700024I/75N93020F00001/B07 and HHSN272201700041I/75N93021F00001/A52. The Virus Pathogen Database and Analysis Resource (ViPR), as part of the Bacterial and Viral Bioinformatics Resource Center (BV-BRC), has been wholly funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract 75N93019C00076. We have no conflicts of interest in this work. Publisher Copyright: {\textcopyright} 2022 American Society for Microbiology. All rights reserved.",

year = "2022",

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doi = "10.1128/jvi.00833-22",

language = "English (US)",

volume = "96",

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AU - Vermillion, Meghan S.

AU - Dearing, Justin

AU - Zhang, Yun

AU - Adney, Danielle R.

AU - Scheuermann, Richard H.

AU - Pekosz, Andrew

AU - Bart Tarbet, E.

N1 - Funding Information: This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contracts HHSN272201700024I/75N93020F00001/B07 and HHSN272201700041I/75N93021F00001/A52. The Virus Pathogen Database and Analysis Resource (ViPR), as part of the Bacterial and Viral Bioinformatics Resource Center (BV-BRC), has been wholly funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract 75N93019C00076. We have no conflicts of interest in this work. Publisher Copyright: © 2022 American Society for Microbiology. All rights reserved.

PY - 2022/8

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N2 - Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in children. Currently, there are no approved vaccines or treatments for EV-D68 infection, and there is a paucity of data related to the virus and host-specific factors that predict disease severity and progression to the neurologic syndrome. EV-D68 infection of various animal models has served as an important platform for characterization and comparison of disease pathogenesis between historic and contemporary isolates. Still, there are significant gaps in our knowledge of EV-D68 pathogenesis that constrain the development and evaluation of targeted vaccines and antiviral therapies. Continued refinement and characterization of animal models that faithfully reproduce key elements of EV-D68 infection and disease is essential for ensuring public health preparedness for future EV-D68 outbreaks.

AB - Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in children. Currently, there are no approved vaccines or treatments for EV-D68 infection, and there is a paucity of data related to the virus and host-specific factors that predict disease severity and progression to the neurologic syndrome. EV-D68 infection of various animal models has served as an important platform for characterization and comparison of disease pathogenesis between historic and contemporary isolates. Still, there are significant gaps in our knowledge of EV-D68 pathogenesis that constrain the development and evaluation of targeted vaccines and antiviral therapies. Continued refinement and characterization of animal models that faithfully reproduce key elements of EV-D68 infection and disease is essential for ensuring public health preparedness for future EV-D68 outbreaks.

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Animal Models of Enterovirus D68 Infection and Disease

Abstract

Keywords

ASJC Scopus subject areas

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