Animal Models of Drug Abuse: Place and Taste Conditioning

Catherine M. Davis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Preclinical animal research has contributed greatly to our understanding of numerous human disease states and will continue to provide a method for investigating the various biochemical events, physiological processes, and behavioral implications of various diseases. For substance abuse and dependence, this research has enabled scientists to gain a greater understanding of the neurochemical events involved in the brain's response to drugs, both licit and illicit, and to provide a means by which to design and test novel pharmaco-therapeutic interventions. To enable these discoveries, scientists have developed numerous animal models that attempt to replicate human drug addiction. The current review explores two popular Pavlovian conditioning procedures, conditioned place preference and conditioned taste aversion, which are used to investigate the rewarding and aversive effects (respectively) of drugs of abuse. For each procedure, a brief history of the field is followed by the advantages of the procedures and a step-by-step explanation of each procedure's conditioning protocol.

Original languageEnglish (US)
Title of host publicationAnimal Models for the Study of Human Disease
PublisherElsevier Inc.
Pages681-707
Number of pages27
ISBN (Print)9780124158948
DOIs
StatePublished - Jul 2013

Keywords

  • Animal models
  • Aversion
  • Conditioned place preference (CPP)
  • Conditioned taste aversion (CTA)
  • Drug abuse
  • Reward

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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