Animal models for protein pneumococcal vaccine evaluation: A summary

M. C. Steinhoff

Research output: Contribution to journalArticlepeer-review


This paper summarizes the discussion and viewpoints from a recent meeting regarding the use of animal models for pneumococcal protein vaccines. A wide spectrum of workers in this field met to discuss the animal species to be used in models, the approach of passive and active protection, the characteristics of challenge pneumococcal strains, inducing disease syndromes by a variety of routes of challenge, the determination of specific endpoints to assess effectiveness, the correlates of protection and other details of experimental design and analysis. Vaccine regulatory aspects were discussed. The document concludes with a series of questions that remain to be investigated.

Original languageEnglish (US)
Pages (from-to)2465-2470
Number of pages6
Issue number13
StatePublished - Mar 22 2007


  • Animal models
  • Correlates of protection
  • Pneumococcal vaccine
  • Protein

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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