Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

James J. Hobson, Paul Curley, Alison C. Savage, Amer Al-Khouja, Marco Siccardi, Charles Flexner, Caren Freel Meyers, Andrew Owen, Steve P. Rannard

Research output: Contribution to journalArticle

Abstract

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

Original languageEnglish (US)
Pages (from-to)4301-4307
Number of pages7
JournalNanoscale Advances
Volume1
Issue number11
DOIs
StatePublished - Jan 1 2019

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ASJC Scopus subject areas

  • Engineering(all)
  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Chemistry(all)

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