Angle-corrected imaging transcranial Doppler sonography versus imaging and nonimaging transcranial Doppler sonography in children with sickle cell disease

Jaroslaw Krejza, W. Rudzinski, M. A. Pawlak, M. Tomaszewski, R. Ichord, J. Kwiatkowski, D. Gor, E. R. Melhem

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Nonimaging transcranial Doppler sonography (TCD) and imaging TCD (TCDI) are used for determination of the risk of stroke in children with sickle cell disease (SCD). The purpose was to compare angle-corrected, uncorrected TCDI, and TCD blood flow velocities in children with SCD. MATERIALS AND METHODS: A total of 37 children (mean age, 7.8 ± 3.0 years) without intracranial arterial narrowing determined with MR angiography, were studied with use of TCD and TCDI at the same session. Depth of insonation and TCDI mean velocities with and without correction for the angle of insonation in the terminal internal carotid artery (ICA) and middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries were compared with TCD velocities with use of a paired t test. RESULTS: Two arteries were not found on TCDI compared with 15 not found on TCD. Average angle of insonation in the MCA, ACA, ICA, and PCA was 31°, 44°, 25°, and 29°, respectively. TCDI and TCD mean depth of insonation for all arteries did not differ significantly; however, individual differences varied substantially. TCDI velocities were significantly lower than TCD velocities, respectively, for the right and left sides (mean ± SD): MCA, 106 ± 22 cm/s and 111 ± 33 cm/s versus 130 ± 19 cm/s and 134 ± 26 cm/s; ICA, 90 ± 14 cm/s and 98 ± 27 cm/s versus 117 ± 18 cm/s and 119 ± 23 cm/s; ACA, 74 ± 24 cm/s and 88 ± 25 cm/s versus 105 ± 23 cm/s and 105 ± 31 cm/s; and PCA, 84 ± 27 cm/s and 82 ± 21 cm/s versus 95 ± 23 cm/s and 94 ± 20 cm/s. TCD and angle-corrected TCDI velocities were not statistically different except for higher angle-corrected TCDI values in the left ACA and right PCA. CONCLUSION: TCD velocities are significantly higher than TCDI velocities but are not different from the angle-corrected TCDI velocities. TCDI identifies the major intracranial arteries more effectively than TCD.

Original languageEnglish (US)
Pages (from-to)1613-1618
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume28
Issue number8
DOIs
StatePublished - Sep 2007
Externally publishedYes

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Doppler Transcranial Ultrasonography
Sickle Cell Anemia
Passive Cutaneous Anaphylaxis
Internal Carotid Artery
Arteries
Posterior Cerebral Artery
Blood Flow Velocity
Individuality
Angiography
Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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Angle-corrected imaging transcranial Doppler sonography versus imaging and nonimaging transcranial Doppler sonography in children with sickle cell disease. / Krejza, Jaroslaw; Rudzinski, W.; Pawlak, M. A.; Tomaszewski, M.; Ichord, R.; Kwiatkowski, J.; Gor, D.; Melhem, E. R.

In: American Journal of Neuroradiology, Vol. 28, No. 8, 09.2007, p. 1613-1618.

Research output: Contribution to journalArticle

Krejza, Jaroslaw ; Rudzinski, W. ; Pawlak, M. A. ; Tomaszewski, M. ; Ichord, R. ; Kwiatkowski, J. ; Gor, D. ; Melhem, E. R. / Angle-corrected imaging transcranial Doppler sonography versus imaging and nonimaging transcranial Doppler sonography in children with sickle cell disease. In: American Journal of Neuroradiology. 2007 ; Vol. 28, No. 8. pp. 1613-1618.
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abstract = "BACKGROUND AND PURPOSE: Nonimaging transcranial Doppler sonography (TCD) and imaging TCD (TCDI) are used for determination of the risk of stroke in children with sickle cell disease (SCD). The purpose was to compare angle-corrected, uncorrected TCDI, and TCD blood flow velocities in children with SCD. MATERIALS AND METHODS: A total of 37 children (mean age, 7.8 ± 3.0 years) without intracranial arterial narrowing determined with MR angiography, were studied with use of TCD and TCDI at the same session. Depth of insonation and TCDI mean velocities with and without correction for the angle of insonation in the terminal internal carotid artery (ICA) and middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries were compared with TCD velocities with use of a paired t test. RESULTS: Two arteries were not found on TCDI compared with 15 not found on TCD. Average angle of insonation in the MCA, ACA, ICA, and PCA was 31°, 44°, 25°, and 29°, respectively. TCDI and TCD mean depth of insonation for all arteries did not differ significantly; however, individual differences varied substantially. TCDI velocities were significantly lower than TCD velocities, respectively, for the right and left sides (mean ± SD): MCA, 106 ± 22 cm/s and 111 ± 33 cm/s versus 130 ± 19 cm/s and 134 ± 26 cm/s; ICA, 90 ± 14 cm/s and 98 ± 27 cm/s versus 117 ± 18 cm/s and 119 ± 23 cm/s; ACA, 74 ± 24 cm/s and 88 ± 25 cm/s versus 105 ± 23 cm/s and 105 ± 31 cm/s; and PCA, 84 ± 27 cm/s and 82 ± 21 cm/s versus 95 ± 23 cm/s and 94 ± 20 cm/s. TCD and angle-corrected TCDI velocities were not statistically different except for higher angle-corrected TCDI values in the left ACA and right PCA. CONCLUSION: TCD velocities are significantly higher than TCDI velocities but are not different from the angle-corrected TCDI velocities. TCDI identifies the major intracranial arteries more effectively than TCD.",
author = "Jaroslaw Krejza and W. Rudzinski and Pawlak, {M. A.} and M. Tomaszewski and R. Ichord and J. Kwiatkowski and D. Gor and Melhem, {E. R.}",
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T1 - Angle-corrected imaging transcranial Doppler sonography versus imaging and nonimaging transcranial Doppler sonography in children with sickle cell disease

AU - Krejza, Jaroslaw

AU - Rudzinski, W.

AU - Pawlak, M. A.

AU - Tomaszewski, M.

AU - Ichord, R.

AU - Kwiatkowski, J.

AU - Gor, D.

AU - Melhem, E. R.

PY - 2007/9

Y1 - 2007/9

N2 - BACKGROUND AND PURPOSE: Nonimaging transcranial Doppler sonography (TCD) and imaging TCD (TCDI) are used for determination of the risk of stroke in children with sickle cell disease (SCD). The purpose was to compare angle-corrected, uncorrected TCDI, and TCD blood flow velocities in children with SCD. MATERIALS AND METHODS: A total of 37 children (mean age, 7.8 ± 3.0 years) without intracranial arterial narrowing determined with MR angiography, were studied with use of TCD and TCDI at the same session. Depth of insonation and TCDI mean velocities with and without correction for the angle of insonation in the terminal internal carotid artery (ICA) and middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries were compared with TCD velocities with use of a paired t test. RESULTS: Two arteries were not found on TCDI compared with 15 not found on TCD. Average angle of insonation in the MCA, ACA, ICA, and PCA was 31°, 44°, 25°, and 29°, respectively. TCDI and TCD mean depth of insonation for all arteries did not differ significantly; however, individual differences varied substantially. TCDI velocities were significantly lower than TCD velocities, respectively, for the right and left sides (mean ± SD): MCA, 106 ± 22 cm/s and 111 ± 33 cm/s versus 130 ± 19 cm/s and 134 ± 26 cm/s; ICA, 90 ± 14 cm/s and 98 ± 27 cm/s versus 117 ± 18 cm/s and 119 ± 23 cm/s; ACA, 74 ± 24 cm/s and 88 ± 25 cm/s versus 105 ± 23 cm/s and 105 ± 31 cm/s; and PCA, 84 ± 27 cm/s and 82 ± 21 cm/s versus 95 ± 23 cm/s and 94 ± 20 cm/s. TCD and angle-corrected TCDI velocities were not statistically different except for higher angle-corrected TCDI values in the left ACA and right PCA. CONCLUSION: TCD velocities are significantly higher than TCDI velocities but are not different from the angle-corrected TCDI velocities. TCDI identifies the major intracranial arteries more effectively than TCD.

AB - BACKGROUND AND PURPOSE: Nonimaging transcranial Doppler sonography (TCD) and imaging TCD (TCDI) are used for determination of the risk of stroke in children with sickle cell disease (SCD). The purpose was to compare angle-corrected, uncorrected TCDI, and TCD blood flow velocities in children with SCD. MATERIALS AND METHODS: A total of 37 children (mean age, 7.8 ± 3.0 years) without intracranial arterial narrowing determined with MR angiography, were studied with use of TCD and TCDI at the same session. Depth of insonation and TCDI mean velocities with and without correction for the angle of insonation in the terminal internal carotid artery (ICA) and middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries were compared with TCD velocities with use of a paired t test. RESULTS: Two arteries were not found on TCDI compared with 15 not found on TCD. Average angle of insonation in the MCA, ACA, ICA, and PCA was 31°, 44°, 25°, and 29°, respectively. TCDI and TCD mean depth of insonation for all arteries did not differ significantly; however, individual differences varied substantially. TCDI velocities were significantly lower than TCD velocities, respectively, for the right and left sides (mean ± SD): MCA, 106 ± 22 cm/s and 111 ± 33 cm/s versus 130 ± 19 cm/s and 134 ± 26 cm/s; ICA, 90 ± 14 cm/s and 98 ± 27 cm/s versus 117 ± 18 cm/s and 119 ± 23 cm/s; ACA, 74 ± 24 cm/s and 88 ± 25 cm/s versus 105 ± 23 cm/s and 105 ± 31 cm/s; and PCA, 84 ± 27 cm/s and 82 ± 21 cm/s versus 95 ± 23 cm/s and 94 ± 20 cm/s. TCD and angle-corrected TCDI velocities were not statistically different except for higher angle-corrected TCDI values in the left ACA and right PCA. CONCLUSION: TCD velocities are significantly higher than TCDI velocities but are not different from the angle-corrected TCDI velocities. TCDI identifies the major intracranial arteries more effectively than TCD.

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