Abstract
Background. Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere. Here, we present an angiosarcoma of the neck occurring after curative chemoradiation. Methods. This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx. Therapy consisted of 3 cycles of induction cisplatin/ 5-fluorouracil chemotherapy followed by radiotherapy. The patient did well until developing a rapidly progressive lesion of the left neck. Examination showed a 7-cm mass and biopsy revealed angiosarcoma. CT scans assessed the local extent of the tumor and ruled out metastatic disease prior to initiating therapy. Results. Therapy consisted of 4 cycles of paclitaxel chemotherapy. At completion, examination revealed mild induration of the neck with near-complete resolution of the mass. Imaging confirmed this excellent response. Conclusion. This rare therapy-related second malignancy developed after curative larynx-preserving treatment. Paclitaxel was an effective therapy in this setting.
Original language | English (US) |
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Pages (from-to) | 829-832 |
Number of pages | 4 |
Journal | Head and Neck |
Volume | 31 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2009 |
Externally published | Yes |
Keywords
- Angiosarcoma
- Induction chemotherapy
- Larynx
- Radiation
- Squamous cell carcinoma
ASJC Scopus subject areas
- Otorhinolaryngology