Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx

Patrick J. Gagnon, Chad Galderisi, Brandi R. Page, John M. Holland

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere. Here, we present an angiosarcoma of the neck occurring after curative chemoradiation. Methods. This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx. Therapy consisted of 3 cycles of induction cisplatin/ 5-fluorouracil chemotherapy followed by radiotherapy. The patient did well until developing a rapidly progressive lesion of the left neck. Examination showed a 7-cm mass and biopsy revealed angiosarcoma. CT scans assessed the local extent of the tumor and ruled out metastatic disease prior to initiating therapy. Results. Therapy consisted of 4 cycles of paclitaxel chemotherapy. At completion, examination revealed mild induration of the neck with near-complete resolution of the mass. Imaging confirmed this excellent response. Conclusion. This rare therapy-related second malignancy developed after curative larynx-preserving treatment. Paclitaxel was an effective therapy in this setting.

Original languageEnglish (US)
Pages (from-to)829-832
Number of pages4
JournalHead and Neck
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Keywords

  • Angiosarcoma
  • Induction chemotherapy
  • Larynx
  • Radiation
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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