Angiopoietin-1 regulates brain endothelial permeability through PTPN-2 mediated tyrosine dephosphorylation of occludin

Agriculture & Biology

• angiopoietin-1 100%
• protein-tyrosine-phosphatase 77%
• dephosphorylation 65%
• tyrosine 50%
• permeability 46%
• tight junctions 39%
• brain 38%
• endothelial cells 32%
• blood-brain barrier 31%
• thrombin 26%
• phosphorylation 13%
• confocal microscopy 8%
• endothelium 8%
• agonists 7%
• ligands 7%
• inflammation 7%
• blood vessels 6%
• therapeutics 6%
• pretreatment 5%
• receptors 5%
• assays 4%
• proteins 2%
• methodology 2%

Medicine & Life Sciences

• Angiopoietin-1 77%
• Occludin 71%
• Protein Tyrosine Phosphatases 67%
• Tyrosine 50%
• Permeability 47%
• Tight Junctions 31%
• Thrombin 27%
• Endothelial Cells 27%
• Brain 26%
• Blood-Brain Barrier 26%
• Herpes Zoster 20%
• human ANGPT1 protein 18%
• Non-Receptor Protein Tyrosine Phosphatases 16%
• Phosphorylation 12%
• Tight Junction Proteins 11%
• Confocal Microscopy 8%
• Endothelium 8%
• Ligands 6%
• Inflammation 5%
• Blood Vessels 5%
• In Vitro Techniques 4%
• Therapeutics 1%

Chemical Compounds

• Tyrosine 50%
• Permeability 43%
• Thrombin 25%
• Protein 22%
• Confocal Microscopy 8%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 8%
• Disorder 6%
• Protective 6%
• Ligand 3%