Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania

Anne Marie Darling, Chloe R. McDonald, Andrea L. Conroy, Kyla T. Hayford, W. Conrad Liles, Molin Wang, Said Aboud, Willy S. Urassa, Kevin C. Kain, Wafaie W. Fawzi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective We sought to investigate the relationship between a panel of angiogenic and inflammatory biomarkers measured in midpregnancy and small-for-gestational-age (SGA) outcomes in sub-Saharan Africa. Study Design Concentrations of 18 angiogenic and inflammatory biomarkers were determined in 432 pregnant women in Dar es Salaam, Tanzania, who participated in a trial examining the effect of multivitamins on pregnancy outcomes. Infants falling below the 10th percentile of birthweight for gestational age relative to the applied growth standards were considered SGA. Multivariate binomial regression models with the log link function were used to determine the relative risk of SGA associated with increasing quartiles of each biomarker. Restricted cubic splines were used to test for nonlinearity of these associations. Results A total of 60 participants (13.9%) gave birth to SGA infants. Compared to those in the first quartile, the risk of SGA was reduced among those in the fourth quartiles of vascular endothelial growth factor-A (adjusted risk ratio [RR], 0.38; 95% confidence interval [CI], 0.19-0.74), placental growth factor (adjusted RR, 0.28; 95% CI, 0.12-0.61), soluble fms-like tyrosine kinase-1 (adjusted RR, 0.48; 95% CI, 0.23-1.01), monocyte chemoattractant protein-1 (adjusted RR, 0.48; 95% CI, 0.25-0.92), and leptin (adjusted RR, 0.46; 95% CI, 0.22-0.96). Conclusion Our findings provide evidence of altered angiogenic and inflammatory mediators, at midpregnancy, in women who went on to deliver SGA infants.

Original languageEnglish (US)
Pages (from-to)509.e1-509.e8
JournalAmerican journal of obstetrics and gynecology
Volume211
Issue number5
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • angiogenesis
  • inflammation
  • small for gestational age

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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