Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models

M. S. Lee, E. J. Moon, S. W. Lee, M. S. Kim, K. W. Kim, Y. J. Kim

Research output: Contribution to journalArticle

Abstract

The excessive growth of a tumor requires high rates of glucose uptake and glycolysis and continuous recruitment of new blood vessels. Here, we provide several lines of evidence showing that pyruvic acid, the end product of glycolysis, exhibits strong angiogenic activity. Pyruvic acid promoted angiogenesis in chorioallantoic membrane assay and in vivo mouse Matrigel plug assay. Pyruvic acid also positively affects angiogenic cascade, DNA synthesis, migration, and tube formation in bovine aortic endothelial cells. Furthermore, mRNA expression of fibroblast growth factor receptor-2 and vascular endothelial growth factor was enhanced by pyruvic acid. These results strongly suggest that pyruvic acid plays an important role in angiogenesis for tumor growth and metastasis.

Original languageEnglish (US)
Pages (from-to)3290-3293
Number of pages4
JournalCancer Research
Volume61
Issue number8
StatePublished - Apr 15 2001
Externally publishedYes

Fingerprint

Pyruvic Acid
Glycolysis
Receptor, Fibroblast Growth Factor, Type 2
Chorioallantoic Membrane
Growth
Vascular Endothelial Growth Factor A
Blood Vessels
Neoplasms
Endothelial Cells
In Vitro Techniques
Neoplasm Metastasis
Glucose
Messenger RNA
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lee, M. S., Moon, E. J., Lee, S. W., Kim, M. S., Kim, K. W., & Kim, Y. J. (2001). Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. Cancer Research, 61(8), 3290-3293.

Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. / Lee, M. S.; Moon, E. J.; Lee, S. W.; Kim, M. S.; Kim, K. W.; Kim, Y. J.

In: Cancer Research, Vol. 61, No. 8, 15.04.2001, p. 3290-3293.

Research output: Contribution to journalArticle

Lee, MS, Moon, EJ, Lee, SW, Kim, MS, Kim, KW & Kim, YJ 2001, 'Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models', Cancer Research, vol. 61, no. 8, pp. 3290-3293.
Lee MS, Moon EJ, Lee SW, Kim MS, Kim KW, Kim YJ. Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. Cancer Research. 2001 Apr 15;61(8):3290-3293.
Lee, M. S. ; Moon, E. J. ; Lee, S. W. ; Kim, M. S. ; Kim, K. W. ; Kim, Y. J. / Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. In: Cancer Research. 2001 ; Vol. 61, No. 8. pp. 3290-3293.
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