Angiogenesis-related microRNAs in colon cancer

Liu Hong, Yu Han, Yi Zhou, Ahuja Nita

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Angiogenesis, for its fundamental role in cancer growth and metastasis, has become an appealing target in cancer therapy. A number of angiogenesis-related microRNAs (miRNAs) are under investigation and they can affect the cancerous phenotype of malignant cells. Areas covered: The authors review the recent advances in angiogenesis-related miRNAs in human colon cancer. They also envisage future developments toward potential miRNA-based applications to cancer treatment. Expert opinion: Angiogenesis-related miRNAs may reasonably be considered as a valuable cancer therapeutic tool. More investigations should be performed to promote therapeutic-clinical research of miRNAs in patients with colon cancer.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume13
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Angiogenesis
  • Colon cancer
  • MiR-107
  • MiR-145
  • MiR-194
  • MiR-27a
  • MiR-802
  • MicroRNA

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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