Angiogenesis in the lung

Lindsey Eldridge, Elizabeth M. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Both systemic (tracheal and bronchial) and pulmonary circulations perfuse the lung. However, documentation of angiogenesis of either is complicated by the presence of the other. Well-documented angiogenesis of the systemic circulations have been identified in asthma, cystic fibrosis, chronic thromboembolism and primary carcinomas. Angiogenesis of the vasa vasorum, which are branches of bronchial arteries, is seen in the walls of large pulmonary vessels after a period of chronic hypoxia. Documentation of increased pulmonary capillaries has been shown in models of chronic hypoxia, after pneumonectomy and in some carcinomas. Although endothelial cell proliferation may occur as part of the repair process in several pulmonary diseases, it is separate from the unique establishment of new functional perfusing networks defined as angiogenesis. Identification of the mechanisms driving the expansion of new vascular beds in the adult needs further investigation. Yet the growth factors and molecular mechanisms of lung angiogenesis remain difficult to separate from underlying disease sequelae. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)1023-1032
Number of pages10
JournalJournal of Physiology
Volume597
Issue number4
DOIs
StatePublished - Feb 15 2019

Keywords

  • Bronchial artery
  • Endothelium
  • Pulmonary artery

ASJC Scopus subject areas

  • Physiology

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