Angiogenesis in Ischemic and Neoplastic Disorders

Research output: Contribution to journalReview articlepeer-review

Abstract

Vascular development involves vasculogenesis, in which endothelial cells form a primary tubular network, as well as angiogenesis, in which vessel size and structure are modified based upon flow and branching occurs to insure that all cells receive adequate O2 delivery. In adults, angiogenesis occurs in response to tissue hypoxia/ischemia and plays an important role in determining the progression of ischemic heart disease and cancer. A critical molecular pathway induced by hypoxia/ischemia is the activation of hypoxia-inducible factor 1, a transcriptional activator of genes encoding vascular endothelial growth factor and other important mediators of angiogenesis. Novel therapeutic approaches that involve stimulating angiogenesis in ischemic tissue and inhibiting angiogenesis in neoplastic tissue are currently being evaluated in clinical trials.

Original languageEnglish (US)
Pages (from-to)17-28
Number of pages12
JournalAnnual review of medicine
Volume54
DOIs
StatePublished - 2003

Keywords

  • Angiopoietin
  • Coronary collateral
  • Hypoxia-inducible factor 1
  • Infarction
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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