Ang-2 but not Ang-1 expression in perivascular soft tissue tumors

Swati Shrestha, Jia Shen, Paulina Giacomelli, Michelle A. Scott, Chia Soo, Kang Ting, Bruno Péault, Sarah M. Dry, Aaron James

Research output: Contribution to journalArticle

Abstract

Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes. Previously, we reported a shared immunophenotype across these related tumor types. Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. Results showed consistent Ang-2 but not Ang-1 expression across tumor types. In summary, the absence of Ang-1 expression distinguishes perivascular from vascular soft tissue tumors. Ang-2 expression is present across perivascular soft tissue tumors, with some variation between histologic subtypes.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalJournal of Orthopaedics
Volume14
Issue number1
DOIs
StatePublished - Mar 1 2017

Keywords

  • Angioleiomyoma
  • Angiopoietin
  • Glomus tumor
  • Myopericytoma
  • Pericyte

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Ang-2 but not Ang-1 expression in perivascular soft tissue tumors'. Together they form a unique fingerprint.

  • Cite this

    Shrestha, S., Shen, J., Giacomelli, P., Scott, M. A., Soo, C., Ting, K., Péault, B., Dry, S. M., & James, A. (2017). Ang-2 but not Ang-1 expression in perivascular soft tissue tumors. Journal of Orthopaedics, 14(1), 147-153. https://doi.org/10.1016/j.jor.2016.07.003