Abstract
Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes. Previously, we reported a shared immunophenotype across these related tumor types. Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. Results showed consistent Ang-2 but not Ang-1 expression across tumor types. In summary, the absence of Ang-1 expression distinguishes perivascular from vascular soft tissue tumors. Ang-2 expression is present across perivascular soft tissue tumors, with some variation between histologic subtypes.
Original language | English (US) |
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Pages (from-to) | 147-153 |
Number of pages | 7 |
Journal | Journal of Orthopaedics |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 2017 |
Keywords
- Angioleiomyoma
- Angiopoietin
- Glomus tumor
- Myopericytoma
- Pericyte
ASJC Scopus subject areas
- Orthopedics and Sports Medicine