Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors

Swati Shrestha; Carolyn Meyers; Jia Shen; Paulina Giacomelli; Michelle A. Scott; Chia Soo; Sarah M. Dry; Kang Ting; Aaron W. James

doi:10.1016/j.jor.2016.12.001

Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors

Swati Shrestha, Carolyn Meyers, Jia Shen, Paulina Giacomelli, Michelle A. Scott, Chia Soo, Sarah M. Dry, Kang Ting, Aaron W. James

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Objective Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance. Methods Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples. Results While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance. Conclusion/implications Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.

Original language	English (US)
Pages (from-to)	154-160
Number of pages	7
Journal	Journal of Orthopaedics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.jor.2016.12.001
State	Published - Mar 1 2017

Keywords

Angiomyolipoma
Angiopoietin
Lymphangiomyoma
PEComa
Pericyte
Perivascular epithelioid cell tumor

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.jor.2016.12.001

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@article{955ec8d211604fd190f7f9fa7ef1cc9c,

title = "Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors",

abstract = "Objective Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance. Methods Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples. Results While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance. Conclusion/implications Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.",

keywords = "Angiomyolipoma, Angiopoietin, Lymphangiomyoma, PEComa, Pericyte, Perivascular epithelioid cell tumor",

author = "Swati Shrestha and Carolyn Meyers and Jia Shen and Paulina Giacomelli and Scott, {Michelle A.} and Chia Soo and Dry, {Sarah M.} and Kang Ting and James, {Aaron W.}",

note = "Funding Information: The present work was supported by the Translational Research Fund, the Orthopaedic Research and Education Foundation with funding provided by the Musculoskeletal Transplant Foundation, and NIH/NIAMS K08 AR068316-01. The authors thank the staff of UCLA Translational Pathology Core Laboratory, and A.S. James for their excellent technical assistance. Publisher Copyright: {\textcopyright} 2016 Prof. PK Surendran Memorial Education Foundation",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.jor.2016.12.001",

language = "English (US)",

volume = "14",

pages = "154--160",

journal = "Journal of Orthopaedics",

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T1 - Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors

AU - Shrestha, Swati

AU - Meyers, Carolyn

AU - Shen, Jia

AU - Giacomelli, Paulina

AU - Scott, Michelle A.

AU - Soo, Chia

AU - Dry, Sarah M.

AU - Ting, Kang

AU - James, Aaron W.

N1 - Funding Information: The present work was supported by the Translational Research Fund, the Orthopaedic Research and Education Foundation with funding provided by the Musculoskeletal Transplant Foundation, and NIH/NIAMS K08 AR068316-01. The authors thank the staff of UCLA Translational Pathology Core Laboratory, and A.S. James for their excellent technical assistance. Publisher Copyright: © 2016 Prof. PK Surendran Memorial Education Foundation

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance. Methods Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples. Results While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance. Conclusion/implications Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.

AB - Objective Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance. Methods Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples. Results While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance. Conclusion/implications Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.

KW - Angiomyolipoma

KW - Angiopoietin

KW - Lymphangiomyoma

KW - PEComa

KW - Pericyte

KW - Perivascular epithelioid cell tumor

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Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors

Abstract

Keywords

ASJC Scopus subject areas

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