Aneuploidy and cancer

Harith Rajagopalan, Christoph Lengauer

Research output: Contribution to journalArticle

Abstract

In contrast to normal cells, aneuploidy - alterations in the number of chromosomes - is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalNature
Volume432
Issue number7015
DOIs
StatePublished - Nov 18 2004

ASJC Scopus subject areas

  • General

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    Rajagopalan, H., & Lengauer, C. (2004). Aneuploidy and cancer. Nature, 432(7015), 338-341. https://doi.org/10.1038/nature03099