Abstract
In contrast to normal cells, aneuploidy - alterations in the number of chromosomes - is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.
Original language | English (US) |
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Pages (from-to) | 338-341 |
Number of pages | 4 |
Journal | Nature |
Volume | 432 |
Issue number | 7015 |
DOIs | |
State | Published - Nov 18 2004 |
ASJC Scopus subject areas
- General