Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants

Daniele Mandrioli, Fiorella Belpoggi, Ellen K. Silbergeld, Melissa J. Perry

Research output: Contribution to journalReview article

Abstract

Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalEnvironmental Health: A Global Access Science Source
Volume15
Issue number1
DOIs
StatePublished - Oct 12 2016

Keywords

  • Aneuploidy
  • Bioassays
  • Carcinogens
  • Chromosomes
  • Early diagnose
  • Endocrine disruptors
  • Laser scanning microscopy
  • Reproductive toxicants
  • Risk assessment
  • mFISH

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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