Anencephaly: Changes in prenatal detection and birth status, 1972 through 1990

C. J. Limb, L. B. Holmes

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: We assessed at a large university hospital the effect of prenatal diagnosis on the birth of infants with anencephaly between 1972 and 1990. STUDY DESIGN: All 175 affected infants were identified by a postnatal Malformations Surveillance Program, which included stillborn infants and elective terminations in the second trimester. The affected infants were subdivided into those whose mothers had always planned delivery at this hospital (nontransfers) and those whose mothers had planned delivery elsewhere but were transferred after the prenatal detection of the fetal abnormality (transfers). RESULTS: In the 1970s half the infants were anencephaly were born alive; the average gestational age was 35.6 weeks, and only a few were diagnosed prenatally. By 1988 to 1990 all affected infants were diagnosed either by prenatal ultrasonography or as the result of maternal serum α-fetoprotein screening; the parents elected to terminate the pregnancies, and the average gestational age was 19.6 weeks. CONCLUSION: Prenatal detection and the selection by parents of the option of elective termination of pregnancy has altered significantly the birth status of infants with anencephaly since 1972.

Original languageEnglish (US)
Pages (from-to)1333-1338
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume170
Issue number5 I
StatePublished - 1994
Externally publishedYes

Fingerprint

Anencephaly
Parturition
Mothers
Gestational Age
Parents
Prenatal Ultrasonography
Fetal Proteins
Pregnancy
Second Pregnancy Trimester
Prenatal Diagnosis
Serum

Keywords

  • Anencephaly
  • birth status
  • maternal serum α-fetoprotein
  • prenatal detection
  • ultrasonography

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Anencephaly : Changes in prenatal detection and birth status, 1972 through 1990. / Limb, C. J.; Holmes, L. B.

In: American Journal of Obstetrics and Gynecology, Vol. 170, No. 5 I, 1994, p. 1333-1338.

Research output: Contribution to journalArticle

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