Anemia, red blood cell transfusions, and necrotizing enterocolitis

Akhil Maheshwari, Ravi M. Patel, Robert D. Christensen

Research output: Contribution to journalArticle

Abstract

In the past 15 years, multiple clinical studies have identified a temporal association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC). With some variability, most of these studies indicate that up to one-third of all cases of NEC involving very low-birth weight infants may occur within 24–48 h after receiving a RBC transfusion. There is also evidence that the risk of such transfusion-associated NEC may be higher in infants transfused with the greatest severity of anemia. In this article, we summarize the clinical evidence pertaining to these issues; specifically, the contribution of RBC transfusions, and the contribution of severity of underlying anemia, to the pathogenesis of a type of NEC potentially termed, “transfusion/anemia-associated NEC.”

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalSeminars in Pediatric Surgery
Volume27
Issue number1
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Fingerprint

Erythrocyte Transfusion
Necrotizing Enterocolitis
Anemia
Very Low Birth Weight Infant

Keywords

  • Anemia
  • Intestinal injury
  • NEC
  • RBC
  • Transfusion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Anemia, red blood cell transfusions, and necrotizing enterocolitis. / Maheshwari, Akhil; Patel, Ravi M.; Christensen, Robert D.

In: Seminars in Pediatric Surgery, Vol. 27, No. 1, 01.02.2018, p. 47-51.

Research output: Contribution to journalArticle

Maheshwari, Akhil ; Patel, Ravi M. ; Christensen, Robert D. / Anemia, red blood cell transfusions, and necrotizing enterocolitis. In: Seminars in Pediatric Surgery. 2018 ; Vol. 27, No. 1. pp. 47-51.
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