Anemia of inflammation.

Cindy N. Roy

Research output: Contribution to journalArticle

Abstract

Inflammation arising from various etiologies, including infection, autoimmune disorders, chronic diseases, and aging, can promote anemia. The anemia of inflammation (AI) is most often normocytic and normochromic and is usually mild. Characteristic changes in systemic iron handling, erythrocyte production, and erythrocyte life span all contribute to AI. The preferred treatment is directed at the underlying disease. However, when the inflammatory insult is intractable, or the cause has not been diagnosed, there are limited options for treatment of AI. Because anemia is a comorbid condition that is associated with poor outcomes in various chronic disease states, understanding its pathogenesis and developing new tools for its treatment should remain a priority. Hepcidin antimicrobial peptide has taken center stage in recent years as a potent modulator of iron availability. As the technology for quantitative hepcidin analysis improves, hepcidin's role in various disease states is also being revealed. Recent insights concerning the regulatory pathways that modify hepcidin expression have identified novel targets for drug development. As the field advances with such therapeutics, the analysis of the impact of normalized hemoglobin on disease outcomes will confirm whether anemia is a reversible independent contributor to the morbidity and mortality associated with inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalHematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
Volume2010
StatePublished - 2010

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Hepcidins
Anemia
Inflammation
Chronic Disease
Iron
Erythrocytes
Hemoglobins
Technology
Morbidity
Peptides
Mortality
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anemia of inflammation. / Roy, Cindy N.

In: Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, Vol. 2010, 2010, p. 276-280.

Research output: Contribution to journalArticle

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