TY - JOUR
T1 - Anemia in thyroid diseases
AU - Fein, H. G.
AU - Rivlin, R. S.
N1 - Funding Information:
Research supported by U.S. Public Health Service research grants, AM-15265 and CA-12126, and by a grant from the Stella and Charles Guttman Foundation. Mr. Feinis the recip-ient of an American Medical Association Goldberger Medical Student Research Fellow-ship for 1974.
PY - 1975
Y1 - 1975
N2 - Thyroid hormones generally stimulate erythropoiesis. These agents also increase erythrocyte 2,3 DPG concentrations, which serve to enhance the delivery of oxygen to tissues. In the absence of thyroid hormones, anemia frequently develops and may be normocytic, hypochromic microcytic, or macrocytic. Anemia is an uncommon finding in hyperthyroidism but when present may be morphologically similar to that observed in hypothyroidism. Pernicious anemia has been strongly associated with hypothyroidism, hyperthyroidism, and thyroiditis. Complete correction of anemia often requires restoration of thyroid function as well as specific hematinic therapy. Continued attention to hematologic status is essential in the management of patients with thyroid diseases.
AB - Thyroid hormones generally stimulate erythropoiesis. These agents also increase erythrocyte 2,3 DPG concentrations, which serve to enhance the delivery of oxygen to tissues. In the absence of thyroid hormones, anemia frequently develops and may be normocytic, hypochromic microcytic, or macrocytic. Anemia is an uncommon finding in hyperthyroidism but when present may be morphologically similar to that observed in hypothyroidism. Pernicious anemia has been strongly associated with hypothyroidism, hyperthyroidism, and thyroiditis. Complete correction of anemia often requires restoration of thyroid function as well as specific hematinic therapy. Continued attention to hematologic status is essential in the management of patients with thyroid diseases.
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U2 - 10.1016/S0025-7125(16)31963-0
DO - 10.1016/S0025-7125(16)31963-0
M3 - Article
C2 - 1099360
AN - SCOPUS:0016837152
SN - 0025-7125
VL - 59
SP - 1133
EP - 1145
JO - Medical Clinics of North America
JF - Medical Clinics of North America
IS - 5
ER -