Anemia and risk for cognitive decline in chronic kidney disease

CRIC Study Investigators

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Background: Anemia is common among patients with chronic kidney disease (CKD) but its health consequences are poorly defined. The aim of this study was to determine the relationship between anemia and cognitive decline in older adults with CKD. Methods: We studied a subgroup of 762 adults age ≥55 years with CKD participating in the Chronic Renal Insufficiency Cohort (CRIC) study. Anemia was defined according to the World Health Organization criteria (hemoglobin 2, 349 (46 %) had anemia. Anemia was not independently associated with baseline cognitive impairment on any test after adjustment for demographic and clinical characteristics. Over a median 2.9 (IQR 2.6-3.0) years of follow-up, there was no independent association between anemia and change in cognitive function on any of the six cognitive tests. Conclusions: Among older adults with CKD, anemia was not independently associated with baseline cognitive function or decline.

Original languageEnglish (US)
Article number226
JournalBMC Nephrology
Issue number1
StatePublished - Jan 28 2016



  • Anemia
  • CKD
  • Cognitive decline

ASJC Scopus subject areas

  • Nephrology

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