Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue

Ingrid B J K Joseph, Joel B. Nelson, Samuel R Denmeade, John Tod Isaacs

Research output: Contribution to journalArticle

Abstract

In previous studies, we have demonstrated that androgen ablation- induced growth inhibition of androgen-responsive PC-82 and A-2 human prostate cancer xenografts involves not only direct activation of programmed (apoptotic) death of these cells but also indirect activation of this death process via a decrease in tumor angiogenesis secondary to a reduction in tumor vascular endothelial growth factor (VEGF) levels. To determine whether androgens consistently regulate angiogenesis via control of VEGF levels, an additional human (i.e., LnCaP) and two rodent (i.e., Dunning G and H) androgen-sensitive prostate cancer sublines were tested. Androgen ablation causes a decrease in the subsequent growth rate of each of these three additional prostate cancer sublines, and this growth inhibition is consistently associated with a >60% reduction in tumor VEGF levels. To examine whether androgens regulate VEGF levels not only in malignant but also in normal prostatic tissue, male rats were castrated, and the temporal changes in the VEGF content of ventral prostate tissue were determined. One week after castration, VEGF content decreased to

Original languageEnglish (US)
Pages (from-to)2507-2511
Number of pages5
JournalClinical Cancer Research
Volume3
Issue number12 I
StatePublished - Dec 1997

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Vascular Endothelial Growth Factor A
Androgens
Prostatic Neoplasms
Growth
Neoplasms
Castration
varespladib methyl
Heterografts
Prostate
Rodentia
Cell Death

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue. / Joseph, Ingrid B J K; Nelson, Joel B.; Denmeade, Samuel R; Isaacs, John Tod.

In: Clinical Cancer Research, Vol. 3, No. 12 I, 12.1997, p. 2507-2511.

Research output: Contribution to journalArticle

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