Androgens and prostate cancer: Are the descriptors valid?

Pradip Roy-Burman; Donald J. Tindall; Diane M. Robins; Norman M. Greenberg; Mary J.C. Hendrix; Suresh Mohla; Robert H. Getzenberg; John T. Isaacs; Kenneth J. Pienta

doi:10.4161/cbt.4.1.1563

Androgens and prostate cancer: Are the descriptors valid?

Pradip Roy-Burman, Donald J. Tindall, Diane M. Robins, Norman M. Greenberg, Mary J.C. Hendrix, Suresh Mohla, Robert H. Getzenberg, John T. Isaacs, Kenneth J. Pienta

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (Al)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.

Original language	English (US)
Pages (from-to)	4-5
Number of pages	2
Journal	Cancer Biology and Therapy
Volume	4
Issue number	1
DOIs	https://doi.org/10.4161/cbt.4.1.1563
State	Published - Jan 2005

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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title = "Androgens and prostate cancer: Are the descriptors valid?",

abstract = "The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that {"}androgen-independent (Al){"} cancer should be more accurately termed {"}androgen depletion-independent (ADI){"} cancer.",

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AU - Roy-Burman, Pradip

AU - Tindall, Donald J.

AU - Robins, Diane M.

AU - Greenberg, Norman M.

AU - Hendrix, Mary J.C.

AU - Mohla, Suresh

AU - Getzenberg, Robert H.

AU - Isaacs, John T.

AU - Pienta, Kenneth J.

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AB - The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (Al)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.

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Androgens and prostate cancer: Are the descriptors valid?

Abstract

ASJC Scopus subject areas

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