Androgen receptor content of normal and hyperplastic human prostate

John Trachtenberg, Piroska Bujnovszky, Patrick Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

In an effort to determine whether human benign prostatic hyperplasia (BPH) is characterized by an increase in androgen receptor content, the levels of nuclear and cytosolic androgen receptors were quantitated in normal prostatic tissue obtained from five young men (mean age ± SEM, 26 ± 3 yr) and i n hyperplastic (periurethral) and peripheral prostatic tissues obtained from nine older men (mean age, 62 ± 2 yr). There was no significant difference between the cytosolic or nuclear androgen receptor content of the hyperplastic, peripheral, or normal prostatic tissue. Thus, in this study we were unable to identify an increase in androgen receptor content in BPH. These findings fail to support the hypothesis that increases in androgen receptor content are involved in the pathogenesis of human BPH.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number1
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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