TY - JOUR
T1 - Androgen parameters in hirsute women
T2 - Correlations with body mass index and age
AU - Ruutiainen, K.
AU - Erkkola, R.
AU - Gronroos, M. A.
AU - Kaihola, H. L.
PY - 1988
Y1 - 1988
N2 - The recent work was designed for studying the effects of body mass index (BMI) and age on serum hormone values in hirsute women of reproductive years with nontumorous hyperandrogenism. Two hundred patients were studied in the follicular phase of the cycle. The serum levels of testosterone (T), androstendione (A), or dehydroepiandrosterone sulfate (DHEAS) were not associated with BMI, whereas the T/sex hormone-binding globulin (T/SHBG) ratio was significantly correlated with BMI independently of the effect of age. All serum androgens were significantly negatively correlated with age, and the serum levels were significantly lower in women older than 41 years when compared with women aged 25 years or less. After correcting for the effect of BMI, there was also a negative correlation between the T/SHBG ratio and age. The correlations between serum androgen parameters were calculated. We conclude that already in reproductive years, the age of the patient had modulating effects on serum androgens, and it should be taken into account when studying the hormone profile of hirsute women.
AB - The recent work was designed for studying the effects of body mass index (BMI) and age on serum hormone values in hirsute women of reproductive years with nontumorous hyperandrogenism. Two hundred patients were studied in the follicular phase of the cycle. The serum levels of testosterone (T), androstendione (A), or dehydroepiandrosterone sulfate (DHEAS) were not associated with BMI, whereas the T/sex hormone-binding globulin (T/SHBG) ratio was significantly correlated with BMI independently of the effect of age. All serum androgens were significantly negatively correlated with age, and the serum levels were significantly lower in women older than 41 years when compared with women aged 25 years or less. After correcting for the effect of BMI, there was also a negative correlation between the T/SHBG ratio and age. The correlations between serum androgen parameters were calculated. We conclude that already in reproductive years, the age of the patient had modulating effects on serum androgens, and it should be taken into account when studying the hormone profile of hirsute women.
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U2 - 10.1016/s0015-0282(16)60069-9
DO - 10.1016/s0015-0282(16)60069-9
M3 - Article
C2 - 2969341
AN - SCOPUS:0023752897
SN - 0015-0282
VL - 50
SP - 255
EP - 259
JO - Fertility and sterility
JF - Fertility and sterility
IS - 2
ER -