Large changes in Ihe activity of DNA polymerase activity occur in the soluble fraction of homogenates of the coagulating gland between the second and fifth dav after treatment of castrated rats with testosterone. These alterations in coagulating gland DNA polymerase activity are very similar to those pre viously described in the rat ventral prostate. Such androgen-induced changes in accessory gland DNA polymerase seem to be unrelated to the polyamine content of the organs. Under the same conditions, testosterone administration does not result in any early increases in DNA polymerase activity in rat levator ani muscle.
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